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16 Cards in this Set
- Front
- Back
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Precursor B-cell neoplasm
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B lymphoblastic leukemia
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Pre-germinal center neoplasm
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mantle cell lymphoma
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Germinal center neoplasm
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follicular lymphoma, burkitt, DLBCL, hodgkin lymphoma
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Post Germinal center neoplasm
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marginal zone and MALT lymphoma
lymphoplasmacytic lymphoma CLL plasma cell myeloma |
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T/F CLL is the most common leukemia in children in the US
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False; ALL is the most common in children, CLL most common in adults
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CLL/SCLL blood smear
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characteristic cells - SMUDGE CELLS - B cells are fragile so they break easily
CLL cells are small lymphocytes with clumped chromatin and scanty cytoplasm |
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CLL/SCLL clinical
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often asymptomatic
generalized lymphadenopathy and hepatosplenomegaly hypogammaglobulinemia - increased infection hemolytic anemia or thrombocytopenia due to autoantibodies |
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CD5+ neoplasm
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CLL/SLL
Mantle Cell Lymphoma |
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ANXA1+ neoplasm
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hairy cell leukemia
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zap70
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Ig unmutaed worse prongosis than Ig somatic hypermutated cells
zap70 marker determines unmutated vs hypermutated |
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cytogenetic mutations found in CLL
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13q deletion
trisomy12 11q deletion 17p deletion |
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diagnosis of B-CLL
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lymphocytosis - peripheral and bone marrow
CD5+, CD23+, FMC7-, weak CD22, CD79b (3 or more of these markers = CLL) positive Ig rearrangement |
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markers to differentiate
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CD10 -> follicular lymphoma
FMC7 -> prolymphocytic leukemia CD25+CD103+ -> hairy cells leukemia cyclin D1 -> mantle cell |
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CLL worse prognosis predictive factors
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ZAP-70+ and CD38+ are WORSE
-11q, -17p, -6q are WORSE rapid lymphocyte doubling time in periphery and elevated thymidine kinase, CD23, Beta2 microglobulin |
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CLL better prognosis predictive factors
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mutated CLL is better than unmutaed
-13q is better |
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treatment for CLL
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fluderbin chemotherapy
rituximab - antiCD20 BM transplant |
