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31 Cards in this Set

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name the two requirements of B cell selection
production of funcitonal BCR
quality control for BCR self reactivity
If light chain rearrangement of BCR is successful, it is paired with the heavy chain, which allows cell surface expression of Ig__ molecules
M
Once the cell produces cell surface IgM it is tested for ....
reactivity to self moelcules in the surrounding environment
If signaling through the BCR occurs during quality control what happens
deaht
receptor editing
What are the requirements for successful T cell education
TCR rearrangement
positive selection
MHC restriction and co receptor expression
negative selection
Once it enters the thymus, the developing cell first attempts to produce an ___ TCR that folds up properly and is expressed at the cell surface. If this fails it tires to produce __ tCR
alpha beta
gamma delta
While the TCR gene rearrangement is being carried out, developing T cells do not express either the ___ or ___ co receptors. After stge will express both to become doubl epsoitive thymocytes
CD 4 or 8
where does positive selection take place
cortial regions of thymic lobes
Next comes the step of fitting where with the help of CD4 and CD8 co receptors T cell will be restricted by .....
MHC I or II
Negative selection ensures that the TCR does not have a very high reactivity for ___ peptides presented by the MHC molecule
self
where does negative selection occur
medullary regions of thymic lobes
When the B cells exit the bone marrow there are _____
naive
an important safeguard to prevent inappropriate responses is that in addition to antigen recognition, naive lymphocytes require ______ to become active
co stim
The most important pathway for costim of T cells are CD __ and CD__
80 and 86
What expresses CD80 and CD86 necessary for T cell activation? Where is CD28?
APC cells
on TCR that receives the signal
The combo of TCR stimualtion along with co stim produces an intracellular signaling cascade inthe naive T cell that leads to gene ____
txn
The main cells that are able to efficiently activate naive T cells are ______
DCs
However in order to activate naive T cells, DCs must first activate _____
themselves!
What do DCs do when they receive stimulation through their PRRs due to infection or other inflammatory event
load the antigen they ingested into the MHC molecules
migrate to T cell regions
upregulate co stim molecules
what are three functions of DC
sentinaels that detect danger via innate receptors
carry antigens to secondary lymphoid tissue
present antigens along with critical co stim signals to naive T cells
___ are critical initiators of adatpvie immune responses
DCs
Co stim signals required by naive B can be provided in two ways...
T indep
T dep
In T _____ co stim of naive B cells, naive B are able to become activated if their BCR binds an antigen and at the same time receive co stim from own innate receptors
independent
T indep generally produces Ig__ Abs
IgM
T __ co stim is usually short lived and not much memory
ind
When a _____ ___ cell comes along that has a TCR that recobnizes a peptide from an antigen, it pregulates CD40L and delivers signal to co stim CD40
helper T
T or F. Helpter T cells also secrete cytokines to facilitate B cella ctivation
true
define anergy
when naive lymphocytes encounter antigen without co stim, they require more co stim in order to become active the next time
why is anergy important
autoimmune
CD80 and CD86 are important for
T cell activation
CD40L and CD40 are important for what
B cell activation by helper T cells