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9 Cards in this Set
- Front
- Back
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Object Drugs (need acid for absorption)
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Ketoconazole
Itraconazole (caps, not oral solution) Dapsone EC Tablets |
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Increased pH of Gastric Fluid
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H2 receptor antagonists
Antacids DDI Proton Pump Inhibitors Age |
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Increased pH of Gastric Fluid Management
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Choose alternative agent
Fluconazole, voriconazole Administer drug with acidic drink and separate doses Use liquid formulation of itraconazole |
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Object Drugs
Warfarin PHT Valproic Acid Amiodarone |
Chloral hydrate
Valproic Acid Salicylates |
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Nephrotoxic drugs may ↓ elimination
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Aminoglycosides and amphotericin B
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Increased/decreased reabsorption
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Lithium and thiazides
Lithium and caffeine, theophylline |
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Alteration in urine pH may trap weak organic acids and bases
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NaHCO3 and acetazolamide alkalinize distal tubule, cause ion trapping of ASA and ↑ excretion
May be used in ASA overdose |
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Drugs compete for tubular secretion
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Penicillins/cephalosporins
Probenecid Aspirin Methotrexate |
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Dofetilide (Tikosyn) is eliminated via tubular secretion and competes with others
CI |
Cimetidine
Verapamil Megestrol Ketoconazole Prochlorperazine Trimethoprim (alone or with sulfamethoxazole) HCTZ (alone or with triamterene) |
