Defranco 3.9 - Immunity vocab

genetic immunodeficiency disease caused by inactivating mutations of one of the subunits of NADPH oxidase. In this disease, certain types of bacteria cannot be killed adequately.

Tightly structured spherical inflammatory lesion characterized by central necrosis and containing microorganisms and infected macrophages in various stages of maturation and activation. Interspersed with these are activated CD4 T cells, and surrounding them are epithelioid fibroblasts and activated CD8 T cells. Granulomas ultimately undergo fibrosis and calcification of the outer mantle.

One of three isoforms of NOS, the enzyme that makes nitric oxide, and that is synthesized by phagocytic cells as part of the microbicidal response. The other forms are found in neurons and endothelial cells and are constitutively expressed and regulated by intracellular calcium levels.

Enzyme that degrades the bacterial cell wall component peptidoglycan.

Phagocyte enzyme that upon induced assembly creates reactive oxygen intermediates.

Specialized intracellular vesicle in neutrophils derived from lysosomes and which contains antimicrobial peptides, proteases and other components.

highly reactive and toxic compounds generated from L-arginine by inducible nitric oxide synthase (iNOS).

Highly reactive and toxic compounds generated from molecular oxygen by NADPH oxidase, superoxide dismutase and/or myeloperoxidase.

Specialized intracellular vesicle in neutrophils that contains the membrane-bound components of the NADPH oxidase