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8 Cards in this Set
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What is the MOA of dissociative anesthetics?
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noncompetitive antagonist of NMDA receptors, which prevents glutamate from binding
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What are the systemic effects of dissociative anesthetics?
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increased intraoccular and intracranial pressure
apnystic breathing increased respiratory and salivary secretions muscle twitching (NOT relaxation) hallucinogenic effects increased HR and BP |
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How are dissociative anesthetics metabolized?
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via liver, excreted by kidney
emergence due to redistribution to muscle, fat *damage to liver or kidney can increase duration of action |
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What are the dissociative anesthetics?
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Ketamine, Tiletamine, Phencyclidine
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Are dissociative anesthetics controlled substances?
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Yes, Schedule III or higher!
Human abuse problem |
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How is Tiletamine formulated?
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with zolazepam
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What is the relative potency of the different dissociative anesthetics?
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Ketamine is the least potent, then Tiletamine, then Phencyclidine
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What is ketamine commonly combined with?
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guaifenesin and xylazine
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