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18 Cards in this Set
- Front
- Back
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what do ACE inhibitors do to fetuses
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renal damage
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aminoglycoside bad for fetus because
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CN VIII damage
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DES causes in fetuses...
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vaginal clear cell adenocarcinoma
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tetracyclines in a fetus
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cause stained teeth
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valproic acid in fetus
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causes neural tube defects
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which amino acids are the nuclear localization signals
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lysine, arginine and proline, + charge to bind to DNA
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what inactivates cyclin-CDK
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p21 p27 p57 mediated by p53
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what cyclins, CDK are involved in G1--> S
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cyclinD binds to CDK4 and phophyorylates Rb which comes off E2F and can progress S phase
cyclin E binds to CDK2 which allows cells to go to S phase |
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what cyclins, CDK are involved in G2-->M
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cyclin A binds to CDK 2--> mitotic phase
cyclin B binds to CDK 1 activated by cdc25 breaks down nuclear envelope |
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what molecules provide the framework for DNA and nuclear envelope
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nuclear lamins
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what maust be present on a protein in order for it to get into nucleus
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nuclear localization signal
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what types of proteins are responsible for fostering the progression through the cell cycle
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cyclins and CDK
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which tumor supressor proteins prevent S phase progression
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Rb and p53
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whats I cell disease
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lack of mannose phophorylation so secretion out of cell not in lysosomes
death young corneal clouding coarse facies +/- mental retardation |
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name a heat shock protein
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ubiquitin
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what molecule targets proteins in ER for lysosomes
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mannose 6 phosphate
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how can cells break down proteins?
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ubiquitin proteosome, lysosome, and Ca dependent enzymes
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which cells have a lot of smooth ER
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liver ( hepatocytes) and adrenal cortex- hormone producing
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