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16 Cards in this Set
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- Back
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What are the flouroquinolines?
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ciproFLOXACIN
levoFLOXACIN |
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What is the MoA of flouroquinonlones?
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inhibits DNA gyrase + topoisomerase II/IV --> prevents relaxation of DNA as it uncoils
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What are flouroquinolones used?
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In treatment of UTIs, Prostatitis, Traveler's Diarrhea
Levo: strep pneumo + legionella |
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What are some unique SE of fluoroquinolones?
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1. prolonged QT
2. damage cartilage in fetus |
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What are the Sulfonamides?
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SULFamenthoxazole (SMX)
SULFisoxazole SULFadiazine |
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What is the MoA of sulfonamides?
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PABA antimetabolies inhibit dihyrdopteroate synthetase--> inhibit purine synth
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What are some unique SE of sulfonamides?
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1. hemolysis if G6PD deficient
2. crystalluria + renal failure 3. Kernicterus in infants |
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What is used to treat Hansen's disease (leprosy - Myco leprae), Pneumocystis jiroveci, toxoplasma gondii?
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Dapsone (Sulfone)
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What is the MoA of Dapsone?
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Inhibits dihyropteroate synthetase
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What inhibits bacterial dihydrofolate reductase?
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Trimethoprim (TMP)
- interferes with reduction of folic acid --> inhibits purine synthesis |
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What are unique SE of TMP?
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TMP = Treats Marrow Poorly
- Megaloblastic anemia - Leukopenia - Granulocytopenia |
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When is TMP used?
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used in combo with sulfonamides
- recurrent UTIs - Acute bacterial prostatitis |
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What is the MoA of metronidazole?
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Forms toxic anion metabolites in bacterial cell that damages bacterial DNA
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When is Metronidazole used?
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1. Anaerobes
2. DoC for Bacteroides protozoal with good CSF penetration |
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What is used to treat prostatitis?
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1. Fluoroquinolones
2. TMP 3. Tetracycline - all concentrate in the the prostate |
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What drugs cause phototoxicity?
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Sulfonamides + Tetracycline
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