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17 Cards in this Set
- Front
- Back
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what is drug abuse
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nonmedical drugs use that deviates from approved medical or social patterns
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copulsive drug use
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preocccupation with the use and procurement of a drugs
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addiction
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a behaviorl pattern of compulsvie drug use charactrerized by an overwhelming involvement with the use of the drug high tendecy to relaps wafter withdrawl term should be used in extreme cases of complusive drugs use
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phyical dependence
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altered physiologic state that results from chronic drug use
determined by severity of withdrawl |
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what is withdrawal
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rebound hyperexcitability symptoms are typically the opposite of the drug effects
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what is tolerance
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more drug needed to elicit the same response
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what are the types of tolerance
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drug dispositional, metabolic pharmacokinetic-less drug gets to site of action
pharmicodynamic cellular, or functional, same amount of drug gets there but response is reduced due to down reg of receptors acute tolerance: rapid developing parmacodymic tolerance reverse tolerance(sensittization): intermittant exposure causes a progressive increase in teh sensitivity to the drug |
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what is MOA of CNS stimulants
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inhibti reuptake of biogenic amines primarily dopamine
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cocaine effect
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inhibtis dopamine and NE transporters
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Amphetamine effect
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inhibits dopaming transporter and may stimulate dopamine release
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methylphenidate effect
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inhibits dopamine transporter
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xanthines(caffeine, theophylline) effect
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act as adenosine receptor antagonists
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exctacy(MDMA) effects
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causes degeneration of serotonin nerve terminals
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nicotine effects
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low dose activate nicotinic receptors in autonomic ganglia
high doses antagonize nicotinc receptors in ganglia and stimlate CTZ to induce nasuea and vomiting |
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cannabinoids
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marijuana: agonist at cannabinoid receptors
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psychedelics
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mescaline: agonist at 5HT receptors
LSD: agonist at 5HT receptors Psilocybin: agonist at 5HT receptros Anticholinergics: antagonist at cholinergic receptors |
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Arylcyclohexylamines:
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phencyclidine(PCP) and ketamine- have sigma receptor activity and ane noncompetitive antagonists of the NMDA receptor.
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