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17 Cards in this Set
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- Back
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omeprazole - MOA
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inhibits H-K ATPase in parietal cells
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pantoprazole is a prodrug. where is it activated?
stomach lumen, liver, blood, canalicular space outside parietal cell |
by acid in the canalicular space outside parietal cell
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side effects of omeprazole
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mild GI problems
increased risk pneumonia and possibly hip fractures |
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MOA cimetidine
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block H2 receptor on pariental cell (H2 receptors increase cAMP which increase activity of proton pump)
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side effects of ranitidine
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mild GI problems mainly
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Side effect - gynecomastia
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cimetidine
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which H2 blocker inhibits cytochrome P450 enzymes
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cimetidine
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MOA misoprosol
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activates EP3 (prostaglandin) receptors on parietal cells (decrease cAMP and proton pump activity) and epithelial cells (increase mucous, bicarb production) in stomach
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side effect - lots diarrhea
omeprazole ranitidine misoprostol sucralfate aluminum hydroxide magnesium hydroxide |
misoprostol and magnesium hydroxide
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contraindicated in pregnancy
omeprazole ranitidine misoprostol sucralfate aluminum hydroxide magnesium hydroxide |
misoprostol
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Which drug(s) are used to prevent aspirin or NSAID induced ulcers
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misoprostol, PPIs
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Clinical use sucralfate -
peptic ulcers, GERD or both |
peptic ulcers
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Clinical use omeprazole-
peptic ulcers, GERD or both |
both
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MOA sucralfate
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in low pH - forms a gel that coats ulcer
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3 drug treatment for H.pylori
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PPI and 2 antibiotics
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treatment of Zollinger-Ellison syndrome
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PPI
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4 drug treatment for H.pylori
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2 antibiotics, PPI and bismuth
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