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8 Cards in this Set

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Human Monocytic Ehrlichiosis (Bug)
Organism: Ehrlichia chaffeensis [Gram (-) coccobacilli; take gram staining weakly; obligate intracellular pathogens; zoonotic pathogens]
Human Monocytic Ehrlichiosis (Reservoir, Vector, Transmission)
Reservoir: Deer, dogs
Vector: Lone star tick
Transmission: Tick bite
Human Monocytic Ehrlichiosis (Virulence Factors and Pathogenesis)
Infect leukocytes → (1) phagocytosis (2) Inhibition of phagosome-lysosome fusion + multiplication in cytoplasmic vacuoles - Morula (3) Host cell + phagosome lyses; Primarily infect mononuclear leukocytes (monocytes, macrophages)
Human Monocytic Ehrlichiosis (Clinical, Diagnosis, Treatment)
Clinical Features: Fever, headache, malaise, myalgia. Severe: prolonged fever, renal failure, disseminated intravascular coagulopathy, meningoencephalitis, seizures, coma.
Diagnosis:Clinical presentation + Microscopy: Giemsa (Morulae) + Serologic tests: IFA, PCR
Treatment:Doxycycline
Human Granulocytic Ehrlichiosis (Bug)
Organism: Anaplasma phagocytophila [Gram (-) coccobacilli; take gram staining weakly; obligate intracellular pathogens; zoonotic pathogens]
Human Granulocytic Ehrlichiosis (Reservoir, Vector, Transmission)
Reservoir: Sheep, cattle, rodents, bisons, deer
Vector: Black legged tick
Transmission: Tick bite
Human Granulocytic Ehrlichiosis (Virulence Factors and Pathogenesis)
Infect leukocytes → (1) phagocytosis (2) Inhibition of phagosome-lysosome fusion + multiplication in cytoplasmic vacuoles - Morula (3) Host cell + phagosome lyses; Primarily infects granulocytes (neutrophils)
Human Granulocytic Ehrlichiosis (Clinical, Diagnosis, Treatment)
Clinical Features: Fever, headache, malaise, myalgia. Severe: prolonged fever, renal failure, disseminated intravascular coagulopathy, meningoencephalitis, seizures, coma.
Diagnosis:Clinical presentation + Microscopy: Giemsa (Morulae) + Serologic tests: IFA, PCR
Treatment: Doxycycline