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39 Cards in this Set
- Front
- Back
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woman with galactorrhea-amenorrhea
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prolactinoma
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where is adh produced? stored
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supraoptic nuclei hypothalamus. neurohypofisis
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where is oxytocin produced?
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paraventricular nucleus
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which hormones are produced in adenohypofisis
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gh, lh, fsh, tsh, prl, acth
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why does amenorrhea occur in prl-oma
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inhibition of LHRH
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when is hyperprl-oma physiologic
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early nursing, stress, sleep, nipple stim
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MC func pit adenoma
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prolactinoma
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which type of prl-oma in women? men?
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micro. men macro
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which drugs can cause increase in prl
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drugs that dec dopamine (phenothiazine, metochlopramide)
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what effect does dopamine have on prl
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inhibiting factor
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which are the dopamine depleting agents
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alpha methyldopa, reserpine
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MOA alpha methyldopa
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competitive inh DOPA decarboxylase, which converts L-dopa --> dopamine
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What dz must u r/o before dx hyperprl
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primary hypothyroidism (low t3,t4, HIGH TRH -->act PRL)
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which tx do you give in PRL
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dopamine agonist (BROMOCRIPTINE)
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what is the definition of acromegaly? gigantism?
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exce sec GH adults. children
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Acromeg in 75% caused by what
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pit adenoma *usu macro* that prod GH
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association with median nerve acromeg
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carpal tunnel
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How is Dx acromeg made
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100g gluc PO --> GH >5ng/mL? --> suggestive (nl gluc load should suppress gh)
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What is the tx in acromeg
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bromocriptine, octreotide
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what is the MCCoD acromeg
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cardiac failure
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what are other cod in acromeg
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cord compression, dm, visual field defects
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What can granulomatous dz cause in pituitary
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hypopit
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Sheehan's postpartum necrosis
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PP pit necrosis, suden infarction ant pit
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what is the 1st sign of sheehan
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can't lactate *(can be years pp)
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what is SIADH
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inappropriately (HIGH) sec of ADH
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how is the urine in siadh
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little amount, high concentration
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what is DI
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low ADH, high Urine output, low [ ]
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which CA are ass with SIADH
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oat cell, panc CA
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Clinical findings in SIADH
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H2o retention, ecf expansion with no signs of edema or ht
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what drug would you use in SIADH
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demeclocycline (induces nephrogenic DI)
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what is the most potent inhibitor of AVP action
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demeclocycline
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what is the most sensitive test to run in thyroid disease
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tsh
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in which pt do you see increased tbg levels
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pregnancy, oral contraceptives
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in which pt do you see decreased tbg levels
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nephrotic sd, androgen use
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which ab are present in hashimoto's thyroiditis
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antimicroomal, antithyroglobulin
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which ab is found in graves
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thyroid stimulating immunoglobulin (TSI)
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MCC of hyperthyroidism
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graves (toxic diffuse goiter)
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Non-AI dz of the elderly ass w arrhythmia, CHF, NO ophthalmopathy (toxic multinod goiter)
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plummer dz
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tx graves in pregnancy
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1st tri. ptu/propranolol (low dose, cross plac)
2nd tri. subtotal thyroidectomy qx (no rai) |
