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19 Cards in this Set
- Front
- Back
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fibronectin: binding domain and location
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-binds to integrins, collagen, heparin, heparan sulfate, and hyaluronic acid
-connective tissue, blood plasma and embryonic tissue |
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laminin: binding domain and location
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-integrins, heparan sulfate, collagen IV and enactin
-basal lamina |
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nidogen (enactin): binding domain and location
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-laminin and type IV collagen
-basal lamina |
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tenascin: binding domain and location
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-syndecans and fibronecting
-embryonic tissue |
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chondronectin: binding domain and location
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-collagen II, chondroitin sulfates, hyaluronic acid, and integrins of chondrocytes
-cartilage |
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osteonectin: binding domain and location
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-collagen I, proteoglycans, and integrins of bone cells (osteocytes and osteoblasts)
-bone |
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Type I collagen tissue distribution
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-dermis, tendon, bone, dentin, cementum, fibrocartilage, organ capsules
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Type II collagen tissue distribution
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-hyaline and elastic cartilage
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Type III collagen tissue distribution
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-spleen, liver, lymph nodes, skin, lungs, smooth muscle
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Type IV collagen tissue distribution
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-basal lamina
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type V collagen tissue distribution
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dermis, tendon, bone, fibrocartilage
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type VII collagen distribution
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dermis
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Ehlers-Danlos type IV: defect and clinical consequence
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-COL3A1 encoding type III (reticular fibers)
-varicose veins, aortic rupture, intestinal rupture |
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Ehlers-Danlos type VI: defect and clinical consequence
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-hydroxylation of lysine, destabilizes collagen
-hyperelasticity of skin, rupture of eyeball |
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Ehlers-Danlos type VII: defect and clinical consequence
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-COL1A1 and COL1A2 encoding type I collagen
-joint dislocation and hypermobility of joints |
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scurvey: defect and clinical consequence
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-tropocollagen molecules cannot aggregate into fibrils due to decreases hydroxylation of proline
-gum ulceration and hemorrhages |
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osteogenesis imperfecta: defect and clinical consequence
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-COL1A1, reduced synthesis of type I collagen
-spontaneous fractures and cardiac insufficiency |
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strickler syndrome: defect and clinical consequence
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-COL2A1, type II collagen
-myopia, hypoplasia of mandible, arthritis |
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marfan syndrome: defect and clinical consequence
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-fibrillin 1
-aortic aneurysm or rupture, myopia, detached lens, skeleton defects |
