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28 Cards in this Set
- Front
- Back
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Angiotensin II Increases __+ and ________ Reabsorption
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Na
Water |
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Angiotensin II works to constrict what part of the glomerular capillary?
What affect does this have on the peritubular capillary network? |
the efferent arteriole
decreased capillary hydrostatic pressure, increased filtration fraction, increases peritubular oncotic pressure, decreases peritubular capillary hydrostatic pressure … allows for more reabsorption |
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What hormone does angiotension II stimulate secretion of?
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aldosterone
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What are the three important effects of angiotension II?
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1) causes secretion of aldosterone
2) directly increases Na+ and Water reabsorption 3) constricts efferent arteriole -leads to more reabsorption |
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Ang II increases tubular Na+ transport.
What 3 transporters does it work at? What in the cell decreases? |
Na+/H+ counter-transporter
Na+/HCO3- co-transporter Na+/K+ counter-transporter Camp in the cell decreases |
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In a Sodium depleted person, stimulation of ________ __ causes an increase in the resistance of efferent arterioles – decrease blood flow, increase filt factor, increase Na and H20 Reabsoption
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Angiotensinogen II
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Angiotensin II blockade __________ Na+ reabsorption and blood pressure.
What groups of drugs can do this? |
decreases
ACE inhibitors (captopril, benazipril, ramipril) Ang II antagonists (losartan, candesartin, irbesartan) |
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ACE inhibitors all end in what 4 letters?
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pril
captopril, benazipril, ramipril |
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Ang II antagonists (losartan, candesartin, irbesartan)
decrease ____________ directly inhibit __+ reabsorption decrease _______ arteriolar resistance |
aldosterone
Na efferent |
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Ang II antagonists all end in what 6 letters?
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sartan
(losartan, candesarti(a)n, irbesartan) |
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ACE inhibitors (captopril, benazipril, ramipril)
decrease ____________ directly inhibit __+ reabsorption decrease _______ arteriolar resistance |
aldosterone
Na efferent |
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Atrial natriuretic peptide __________ Na+ excretion
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increases
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What is secreted by the cardiac atria in response to stretch (increased blood volume, injury)?
What does it do? |
Atrial natriuretic peptide
increases Na+ excretion directly inhibits Na+ reabsorption inhibits renin release and aldosterone formation increases GFR helps to minimize blood volume expansion |
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Atrial natriuretic peptide
directly inhibits Na+ reabsorption inhibits _____ release and __________ formation increases ___ helps to minimize blood volume expansion |
renin
aldosterone GFR |
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Sympathetic nervous system _________ Na+ reabsorption
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increases
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Sympathetic nervous system
Directly ________ Na+ reabsorption Stimulates ________ release Decreases GFR and _____ blood flow |
increases
renin renal |
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Increased Arterial Pressure ________ Na+ Reabsorption (Pressure Natriuresis)
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Decreases
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Increased Arterial Pressure Decreases Na+ Reabsorption (Pressure Natriuresis)
-Increased peritubular capillary __________ pressure - Decreased renin and aldosterone -Increased release of intrarenal natriuretic factors - ______________ - _______ |
hydrostatic
prostaglandins EDRF |
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Water is reabsorbed only by osmosis
Increasing the amount of unreabsorbed solutes in the tubules decreases water reabsorption Give a clinical example of this. |
i.e. diabetes mellitus : unreabsorbed glucose in tubules causes diuresis and water loss
i.e. osmotic diuretics (mannitol |
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Abnormal Tubular Function : Increased __________
Conn’s Syndrome: primary aldosterone excess Glucocorticoid Remediable Aldosteronism (GRA): excess aldosterone secretion due to abnormal control of aldosterone synthase by ACTH (genetic) Renin secreting tumor: excess Ang II formation Inappropriate ADH syndrome: excess ADH Liddle’s Syndrome: excess activity of amiloride sensitive Na+ channel (genetic) |
Reabsorption
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Work it through the steps in an aldosterone infusion.
1) What initially happens to Na+ in the blood? 2) What happens to BP? 3) What does BP do to Na+ in the blood? |
there will be excess Na retention, BP will be increasing as a result, once BP maxes out for whatever dose of Aldo being used,Pressure natruesis effect occuring - Na excretion will reach steady state again back to normal
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Excess activity of amiloride sensitive Na+ channel is called _________ Syndrome
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Liddle’s
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Primary aldosterone excess is called _________ Syndrome
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Conn’s
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Decreased Na+ reabsorption and decreased K+ secretion; lack of aldosterone is called ___________ disease
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Addison’s disease:
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In this condition there is decreased water reabsorption, hypernatremia, increased thirst
- nephrogenic - lack of ADH |
Diabetes Insipidus
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Decreased Na+, Ca++, HCO3- reabsorption, hypotension; decreased activity of Na-K-2 Cl transporter in loop of Henle (genetic) is called __________ syndrome
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Bartter’s Syndrome
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In ____________ syndrome you need a very high salt intake (“potato chip diet”)
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Bartter’s Syndrome
Decreased Na+, Ca++, HCO3- reabsorption, hypotension; decreased activity of Na-K-2 Cl transporter in loop of Henle |
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Decreased NaCl reabsorption in Early Distal Tubule in ___________ syndrome.
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Gitelman’s Syndrome
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