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8 Cards in this Set

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What class of antibiotics contains Fidaxomicin?
Macrocyclic
What is the mechanism of action of Fidaxomicin?
Inhibition of RNA polymerase
What is the mechanism of resistance to Fidaxomicin?
Mutations on RNA polymerase where Fidoxamicin binds
What bacteria is Fidaxomicin particularly good at killing? Why?
C. difficile.

Why? It is concentrated into the intestine
What is the absorption of Fidaxomicin?
Minimal when given orally.

This is how it is given though, because it targets GI bugs on the mucosal surface.
Where is the distribution of Fidaxomicin?
Confined primarily to the intestine
What is the metabolism of Fidaxomicin?
The bug is hydrolyzed to an active metabolite.

Half life = 11.7 hours.
What is the excretion of Fidaxomicin?
Fecally.

This MAKES SENSE: it isn't absorbed and doesn't go anywhere else than the intestine!