- Shuffle
Toggle OnToggle Off
- Alphabetize
Toggle OnToggle Off
- Front First
Toggle OnToggle Off
- Both Sides
Toggle OnToggle Off
Front
How to study your flashcards.
Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key
Up/Down arrow keys: Flip the card between the front and back.down keyup key
H key: Show hint (3rd side).h key
PLAY BUTTON
PLAY BUTTON
12 Cards in this Set
- Front
- Back
|
Tumor suppressor genes: Loss of function leads to cancer.
How many alleles need to be damaged? |
Both alleles must be lost for expression of disease.
|
|
Rb (13q)
Rb gene product blocks G1 --> S phase of the cell cycle |
Retinoblastoma, osteosarcoma
|
|
p53 (17p)
p53 gene product blocks G1 --> S phase of the cell cycle |
Most human cancers, Li-Fraumeni Syndrome
|
|
BRCA1 (17q)
DNA Repair protein |
Breast and ovarian cancer
|
|
BRCA2 (13q)
DNA Repair protein |
Breast Cancer
|
|
p16 (9p)
|
Melanoma
|
|
APC (5q)
|
Colorectal cancer
-associated with FAP |
|
WT1 (11p)
|
Wilms' Tumor
WT1 = Wilms' Tumor 1 |
|
NF1 (17q)
|
Neurofibromatosis type 1
|
|
NF2 (22q)
|
Neurofibromatosis type 2
Neurofibromatosis type 2 = chromosome 22 |
|
DPC (18q)
|
Pancreatic Cancer
DPC = Deleted in Pancreatic Cancer |
|
DCC (18q)
|
Colon cancer
DCC = Deleted in Colon Cancer |
