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18 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Action and use of Finasteride?
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5alpha-reductase inhibitor (decreased conversion of testosterone to dihydrotestosterone). Used for BPH and baldness
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Action and use of Flutamide?
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nonsteroidal competitive inhibitor of androgens at the testosterone receptor. Used in prostate ca
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Action and use of ketoconazole?
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inhibit steroid synth; used in polycystic ovarian syndrome to prevent hirsutism
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Action and use of spironolactone?
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inhibit steroid synth; used in polycystic ovarian syndrome to prevent hirsutism
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MOA of sildenafil/vardenafil?
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inhibit cGMP phosphodiesterase causing increased cGMP, smooth musc relax in corpus cavernosum, increased blood flow and erection
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Use of sildenafil/vardenafil?
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treatment of erectile dysfxn
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Toxicity of sildenafil/vardenafil?
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HA, flushing, dyspepsia, blue-green color vision. Risk of life-threatening hypotension in pts taking nitrates
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MOA of leuprolide?
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GnRH analog w/agonist properties when used in pulsatile fashion; antagonist properties when used in continuous fashion (continous causes transient initial burst of LH and FSH)
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Use of leuprolide?
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infertility (pulsatile), prostate ca (continuous w/flutamide), unterine fibroids
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Toxicity of leuprolide?
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antiandrogen, N/V
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MOA of clomiphene?
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partial agonist at estrogen receptors in pituitary gland. Prevents nrm feedback inhibition and increases release of LH and FSH from pituitary…stimulates ovulation
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Use of clomiphene?
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tx of infertility
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Toxicity of clomiphene?
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hot flashes, ovarian enlargement, multiple simultaneous pregnancies, visual disturbances
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MOA of mifepristone (ru-486)?
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competitive inhibitor of progestins at progesterone receptors
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Use of mifepristone?
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abortifactant (prevents implantation)
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None |
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Toxicity of mifepristone (ru-486)?
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heavy bleeding, GI effects (N/V, anorexia), ab pain
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Advantages of oral contraceptives (5)?
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reliable, decreased risk of endometrial/ovarian ca, decreased risk ectopic preg, decreased pelvic infxn, regulation of menses
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Disadvantages of oral contraception (5)?
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taken daily, no STD protection, increased triglycerides, depression/wt gain/nausea/HTN, hypercoaguable state
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