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10 Cards in this Set
- Front
- Back
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Growth factors
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Autocrine stimulation
v-sis: c-sis (B chain of PDGF) |
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Receptor tyrosine kinase
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v-erbB: c-erbB (EGF receptor)
trkA: gene for NGF receptor |
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Non receptor tyrosine kinase
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v-src: c-src (Src Kinase)
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G- Proteins
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v-Hras: cHras (ras-->Raf-mapkk etc)
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Serine-Threonine kinases
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v-raf: c-raf (Raf-1 Kinase)
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Transcription factors
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v-fos: c-fos (transcription factor Fos)
v-myb: c-myb (transcription factor Myb) v-myc: c-myc (transcription factor Myc) |
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Factors controlling apoptosis
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bcl-2: bcl-2 (antiapoptotic protein of Bcl-2 family)
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Chemical carcinogens
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POINT MUTATIONS
-Aromatic hydrocarbons: Benzpyrenes -Nitrosamines -Acridine Dyes: Acridin orange |
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UV radiation and ionizing radiation
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physical carcinogens
-UV radiation-->tautomeric bases and thymine dimers -Ionizing radiation- Chromosomal translocations |
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Viruses
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Oncogenic RNA viruses
Oncogenic DNA viruses |