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10 Cards in this Set

  • Front
  • Back
Growth factors
Autocrine stimulation
v-sis: c-sis (B chain of PDGF)
Receptor tyrosine kinase
v-erbB: c-erbB (EGF receptor)
trkA: gene for NGF receptor
Non receptor tyrosine kinase
v-src: c-src (Src Kinase)
G- Proteins
v-Hras: cHras (ras-->Raf-mapkk etc)
Serine-Threonine kinases
v-raf: c-raf (Raf-1 Kinase)
Transcription factors
v-fos: c-fos (transcription factor Fos)
v-myb: c-myb (transcription factor Myb)
v-myc: c-myc (transcription factor Myc)
Factors controlling apoptosis
bcl-2: bcl-2 (antiapoptotic protein of Bcl-2 family)
Chemical carcinogens
POINT MUTATIONS
-Aromatic hydrocarbons: Benzpyrenes
-Nitrosamines
-Acridine Dyes: Acridin orange
UV radiation and ionizing radiation
physical carcinogens
-UV radiation-->tautomeric bases and thymine dimers
-Ionizing radiation- Chromosomal translocations
Viruses
Oncogenic RNA viruses
Oncogenic DNA viruses