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13 Cards in this Set
- Front
- Back
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What is the etiology of MS
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Autoimmune disease
Destruction of myelin in the CNS |
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What are the different types?
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Relapsing remitting
Primary progressive Secondary Progressive Progressive Relapsing |
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What are the early signs of MS?
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Optic neuritis
Fatigue Weakness Balance deficits/Cerebellar signs |
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What is required for a Dx of MS
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Dissemination of time and space
Decreased latency of evoked potentials IgG in the CSF >15% |
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What does a high score on the EDSS mean?
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10=death
1= normal |
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Explain the components of the EDSS
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Motor function
Cerebellar Function Brainstem function (CN) Sensory fucntion Bowel and Bladder Visual Cerebral (mental) |
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At what levels of the EDSS will the pt be able to amb s an AD?
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<6
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What are the disease modifiers of MS
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Fatigue
Heat Stress Trauma (mental or physical) Infection |
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What are the signs associated with better prognosis in MS?
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Female
<35y/o small area of involvement complete recovery p attacks lower lesion burden on MRI No brainstem/cerebellar involvement Neurologic finding 5year post dx |
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What happens to NCV (nerve conduction velocity in MS?
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decreases
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Explain the immune response
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antigen-->APC-->T-cell-->CD 4+8
CD4--> cytokines--> recruit beta cells -->create IgG CD8-->release cytokines to kill |
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Explain theories of how neurons are destroyed.
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immune cells attack myelin +/- oligodenrocytes --> cells become demyelinated -->gliosis occurs
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What system reviews would you preform?
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Neuromuscular
Musculoskeletal Cardiopulm Integumentary |
