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7 Cards in this Set
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- Back
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what are the three main reasons for GWAS
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advances in genotyping and sequencing technology
most diseases are probably controlled by many mutations linkage mapping is inadequate because you want to find specific alleles |
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more recombination reduces correlations between DNA variants and leads to higher or lower resolution?
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higher
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why do you want to study non related relatives in GWAS?
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because want most recombination possible
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what are the main challenges of GWAS?
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false positives
hidden populations epistasis environmental factors epigenetics |
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what are the keys motivators for GWAS
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drug targets
locate previously unsurveyed DNA variants through their correlations with those that are already surveyed |
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T or F. heritabilites are population specific
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true
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what are the steps of association studies
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ID sample in population
measure disease status and underlying risk factors genotype for SNPS test differences in trait among genotypic class resequence and further investigate |
