Genetics Exam III Lecture 32 Flash Cards

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Title: Genetics Exam III Lecture 32
Description: genetics
Number of Cards: 7
Save Count: 0
Author: reithel8
Created: 2011-12-13
Tags: genetics
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    • Question
    • Answer
    • Side 3
    • what are the three main reasons for GWAS
    • advances in genotyping and sequencing technology
      most diseases are probably controlled by many mutations
      linkage mapping is inadequate because you want to find specific alleles
    • more recombination reduces correlations between DNA variants and leads to higher or lower resolution?
    • higher
    • why do you want to study non related relatives in GWAS?
    • because want most recombination possible
    • what are the main challenges of GWAS?
    • false positives
      hidden populations
      epistasis
      environmental factors
      epigenetics
    • what are the keys motivators for GWAS
    • drug targets
      locate previously unsurveyed DNA variants through their correlations with those that are already surveyed
    • T or F. heritabilites are population specific
    • true
    • what are the steps of association studies
    • ID sample in population
      measure disease status and underlying risk factors
      genotype for SNPS
      test differences in trait among genotypic class
      resequence and further investigate