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21 Cards in this Set

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What is a cholestatic injury?
Bilirubin has difficulty passing through the bile duct
What are liver function tests really?
How well the liver is functioning
PT
INR
Albumin
NOT AST ALT
Where will liver cancers get all their blood supply?
From hepatic arteries--can be used for imaging to see if it stays after portal circulation
What is AST?
Cytosolic enzyme involved in gluconeogenisis and AA metabolism
In hepatocytes--80% in MITOCHONDRIA and 20% CYTOSOL
Where is AST also found?
RED BLOOD CELLS, heart, skeletal muscles, brain, lungs, kidneys
What is ALT?
Cytosolic enzyme involved in gluconeo and AA metabolism that is measured to gauge liver damage
Normal ALT is higher or lower than it should be?
Higher
What is hepatitis?
Any inflammation to hepatocytes causing cell death
What does alcohol do in the liver?
Damages the mitochondria and so the AST will be more elevated
LOOK AT SLIDE 17!!!
LOOK AT SLIDE 17!!!
What are the labs for an acute liver injury?
AST and ALT >1000
When do you see elevated alkaline phosphatase?
Liver damage, osteoblasts(metastatic bone cancers and fractures), intestinal enterocytes, placental syncytiotrophoblasts, renal epithelial cells, leukocytes
Normal serum values are HIGHER for pediatric patients
Alkaline phosphatase in normal to mildly elevated?
PBC or it's coming from bone, intestine, or placenta
Alkaline phosphatase > 1000 and bilirubin < 3 = ?
Infiltrative liver cancer
Alkaline phosphatase and amylase are elevated with Tbili > 3 = ?
Chronic pancreatitis or CA of pancreas
DECREASED ALKALINE PHOSPHATASE = ?
Wilson's disease
Excess copper in blood--copper replaces zinc to make Alk Phos and what is made is bad
What does PT measure?
The extrinsic pathway of coagulation
Albumin normal and LFT's are abnormal = ?
Acute hepatitis or cholangitis
INR < 1.5 = ?
Minimal liver injury
INR 1.5 -- 3 = ?
Acute or chronic liver disease
INR > 3 = ?
Severe acute liver injury