Goldblatt_BonePath1

Non-neoplastic proliferation of granulomatous tissue containing multinucleated giant cells & occuring centrally within bone (jaw bone)

Clinical Features:
->60% under 30
-Female, 70% in mandible
-Most: asymptomatic
Some: pain, swelling, root displacement
-Majority slow-growing

Radiograph: Well-circumscribed unilocular/multilocular radiolucency
-Mimic periapical granuloma, chronic periodontitis, or ameloblastoma

Histology:
-number of multinucleated giant cells in ovoid
-Giant cells may resemble osteoclasts: numerous uniform nuclei distributed in cytoplasm
-Numerous extravasted RBCs

"Brown tumors" seen from hyperparathyroidism are histologically indistinguishable from this

Benign (aggressive) neoplasm occuring in epiphyses of long bones
-Rarely occcurs in Jaws
-Histologically different from CGCG of Jaws

Uncommon developmental condition of jaws showing bilteral enlargement of 2 or 4 quadrants of jaws, maxillary involvement causing slight upturn in the eyes

Clinical Features:
-Onset b/t 2 & 5 years
-Involves jaws bilaterally, almost always mandible
-Enlargement is painless but distorts alveolar ridges, tooth position, occlusion, speech
-Enlargement progresses thru puberty but then slows/regress

Radiographic:
-Bilateral multiocular radiolucencies of the jaws

Histology:
-Number of multinucleated giant cells in fibroblast background
-Looks liek CGCG
-Eosinophilic cuffing of small blood vessels

Non-neoplastic proliferation of granulomatous tissue containing multinucleated giant cells & occuring centrally within bone (jaw bone)

Clinical Features:
->60% under 30
-Female, 70% in mandible
-Most: asymptomatic
Some: pain, swelling, root displacement
-Majority slow-growing

Radiograph: Well-circumscribed unilocular/multilocular radiolucency
-Mimic periapical granuloma, chronic periodontitis, or ameloblastoma

Histology:
-number of multinucleated giant cells in ovoid
-Giant cells may resemble osteoclasts: numerous uniform nuclei distributed in cytoplasm
-Numerous extravasted RBCs

"Brown tumors" seen from hyperparathyroidism are histologically indistinguishable from this

Benign (aggressive) neoplasm occuring in epiphyses of long bones
-Rarely occcurs in Jaws
-Histologically different from CGCG of Jaws

Uncommon developmental condition of jaws showing bilteral enlargement of 2 or 4 quadrants of jaws, maxillary involvement causing slight upturn in the eyes

Clinical Features:
-Onset b/t 2 & 5 years
-Involves jaws bilaterally, almost always mandible
-Enlargement is painless but distorts alveolar ridges, tooth position, occlusion, speech
-Enlargement progresses thru puberty but then slows/regress

Radiographic:
-Bilateral multiocular radiolucencies of the jaws

Histology:
-Number of multinucleated giant cells in fibroblast background
-Looks liek CGCG
-Eosinophilic cuffing of small blood vessels

Treatment:
-Slow disease: followup
Rapid: intervention

Prognosis: lesions tend to slow down (by 4th decade)

A benign empty or fluid containing cavity within bone that is devoid of an epithelial lining

Etiology:
-Trauma/hemmorage theory: blood clot following trauma does not heal by bone regeneration
-Poor venous drainage: buildup of interstitial fluid
-Local bone growth disturbance
-Ischemic marrow necrosis

Clinical Features:
-Any bone -- but common in jaws
-10 & 20 yo
-Mandible
-Males
-80% asymptomatic
-Premolar/molar area most common

Radiograph:
-In a dentulous area, characteristically scalloped between roots of the teeth

Diverse group of mostly non-neoplastic conditions that replace normal bone by fibrous tissue.
-Forms new mineralized product: bone, cementum, their precursors or combo

-REQUIRES clinical & radiographic features -- histologic exam is not enough

Deveopmental non-neoplastic but tumor-like condition: normal bone is repalced by cellular fibrous connective tissue containing irregular trabeculae of newly formed bone
---Polyostoic or Monostotic

Clinical Features:
-limited to a single bone 80% of all cases
-Jaws most common: MAX>mand
-Diagnosed 2nd decade of life
-M=F
-Can involve maxilla & spread to Craniofacial type

-"Ground Glass" appearance
-Mandible involvement may produce buccolingual expansion & bulging of info border, displacement of mandibular canal
-Max involvement: displace maxillary sinus floor
-Max involvement: increased radiodensity at base of skull
-Narrow PDL with Ill-defined lamina dura (blends with adjacent bone)

Histologic:
-Trabeculae of immature bone
-Curvilinear (chinese character shape)