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81 Cards in this Set
- Front
- Back
Dz associated w/ anti-acetylcholine receptor?
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myasthemia gravis
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Dz assoc. w/ anti-centromere Ab?
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CREST Sx 60% and PSS 10%
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Dz assoc. w/ anti-gliadin Ab?
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Celiac Dz (95%)
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Dz assoc. w/ anti-glomerular basement membrane?
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Goodpasture Sx (90%)
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Against what Ab is anti-GBM directed to?
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Collagen Type IV
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What Dz is assoc. w/ anti-islet cel Abs?
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Type I DM
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What Dz is assoc. w/ anti-microsomal Abs?
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Hashimotos (97%)
autoimmune hepatitis (70%) |
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Dz. assoc. w/ anti-mitochondrial Abs?
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primary biliary cirrhosis (90-100%)
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Dz. assoc w/ C-ANCA?
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Wegner's Granulnomatosis
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Dz. assoc. w/ P-ANCA?
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Polyarteritis Nodosa (PAN)
and Hep B associated to PAN |
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Dz. assoc. w/ anti-parietal cell Abs?
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Pernicious Anemia
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Dz. assoc. w/ intrinsic factor Abs?
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Pernicous Anemia Type I (Ab to B12 prevent binding to IF)
Type II (Ab to IF or complex) |
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Dz. assoc. w/ anti-smooth muscle Abs?
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Autoimmune Hepatitis (70%)
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Dz. assoc. w/ anti-thyroglobulin Ab?
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Hashimoto (85%)
Grave's (30%) |
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What Dz is associated w/ myasthemia gravis?
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thymoma (60%)
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HLA relationship of hemochromatosis?
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A3
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HLA relationship of Myasthemia Gravis?
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B8
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HLA relationship of Celiac Dz?
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B8 and DR3
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HLA relationship of Ankylosing Spondylitis?
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B27
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HLA relationship of Multiple Sclerosis?
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DR2
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HLA relationship of Type I DM?
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DR3 and DR4
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HLA relationship of Rheumatoid Arthritis?
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DR4
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What is the MCC of Autoimmune Hemolytic Anemia?
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Warm IgG Lupus
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2nd MCC of Hemolytic Anemia?
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Drug Induced Hemolytic Anemia
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What two drugs used for HT for pregnancy?
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Hydralazine, Methyl-Dopa
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Hydralazine causes?
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Drug Induced Lupus
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MC drug that causes drug-induced Lupus?
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Procainamide
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What Ab is made against alpha-methyl dopa?
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IgG
G is for Gravida |
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What Ab is made against Quinide?
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IgM
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What does IgG activate?
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Macrophages to become active
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What does IgM activate?
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Complement System
MAC C1-C9 |
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What disease causes leukemoid reaction?
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B. pertussis
Scares Pediatricians!!! >60,000 WBCs |
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Mononucleosis caused by ------>
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EBV
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What cell does EBV infect?
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B-Cell
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What is the marker (receptor) for EBV, B-cells?
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CD21
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What drug induces atypical lymphocytes?
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phenytoin
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MOA of Phenytoin?
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Blocks intestinal Conjugase
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What drug causes macrocytic anemia and atypycal lymph?
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Phenytoin
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Where does EBV hide for the rest of the life of the patient?
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Salivary Glands
Kissing Disease |
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What test is diagnostic for Mononucleosis?
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Anti Heterophile Antibody
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What diseases cause eosinophilia?
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Strongyloides
Malaria Type I Yes whipworm |
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MCC of Bud-Chiari Sx?
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polycytemia vera
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Age of ALL?
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0-15
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Age of AML?
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15-40
40-60 |
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Age of CLL?
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>60
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Age of CML?
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40-60
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MC overall Leukemia? ------->
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CLL
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Characteristic of CLL?
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MC generalized non-tender lymphadenopathy >60y ?
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MC Leukemia >60yo?
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CLL
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Where does CLL metastisize to?
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lymph nodes
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49 y.o. 150,000 WBC
1% myeloblasts (<30% blasts) generalized lymphadenopathy |
CML
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Translocation of CML?
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t9;22 of abl gene
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49 y.o. 150,000 WBC
1% myeloblasts (<30%) generalized lymphadenopathy |
CML
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What gene/chromosome is important in CML?
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Philadelphia Chromosome 22
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What translocation is seen in CML?
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t9;22
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What is the gene in t9;22?
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bcr-abl gene
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What two tests are used to Dx CML?
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Philadelphia Chromosome (+) and LAP (low level)
LAP = leukocyte alkaline phosphatase not absorbed by malignant cells |
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What do is the Dx when you see a tear drop cell?
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Agnogenic Myeloid Metaplasia
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Pt. 4yo, w/ generalized non-tender lymphadenopathy, sternal tenderness, hepatosplenomegaly, fever, normocytic anemia, 50,000 WBCs abnormal appearing cells
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ALL
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What antigen is use to detect ALL?
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CALLA
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What does CALLA detect?
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B-cells CD10
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Pt. 65 yo man, hepatosplenomegalic, 90,000 WBC smudge cells, also pt. has hypogammaglobulinemia
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CLL age gives it away
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What leukemia has auer rods in it?
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AML
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What leukemia has lots of auer rods?
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Acute Promyelocytic Leukemia (M3)
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What are the four/five myeloproliferative dz?
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1. polycythemia vera
2. chronic myelogenous leukemia 3. adenogenic myeloid metaplasia 4. essential thrombocytemia myelodysplastic Sx |
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What are the four H's of polycythemia vera?
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1) Hyperviscosity
2) Hypervolemia 3) Histaminemia 4) Hyperuricemia |
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What is the Dx of a patient that complains of itching after taking a shower hot or cold?
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Polycythemia ruba vera
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What is the translocation of Burkitt's Lymphoma?
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t8;14
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What is responsible for Burkitt's Lymphoma?
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EBV
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What do you see in the pathology slides for Burkitt's?
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Starry Sky Appearance
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What are the three K for Burkitt's?
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Kid 8yo
8 is for translocation 8;14 blacK C-Myc |
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What are the stars in Burkitt's?
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Macrophages
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United States where is Burkitt's Located?
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Abdomen (Peyer's Patches, Paraortic Lymph nodes), Testicle also
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African Burkitt's lymphoma MC location?
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Jaw
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What two tissues are resistant to cancer infection?
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Cartilage and Elastic Vessels
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Pat. w/ plaque like lesions w/ inflamatory cells in epidermis?
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Neoplastic epidermis cells Helper T-Cells
Mycosis Fungoides |
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What is a helper T-cell malignancy that involves skin?
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Mycosis Fungoides
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What cell is involved in Mycosis Fungoides?
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Sezary Body
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What is a sezary body?
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Helper T-cell seen in plasma of pat. w/ Mycosis Fungoides
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What substance is secreted and produced by Gastic Adenocarcinoma (Linitis Plastica)?
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Mucin Producer
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What is the appearance of the stomach in linitis plastica?
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diffusely inflitrative (thickened appearance)
mucosa and muscularis produced rigid thick, leather-bottle gastric wall |