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19 Cards in this Set

  • Front
  • Back
when does extracellular matrix remodeling occur 5 processes
ovulation
mammary involution
uterine involution
wound healing
development
regulation of ecm environment
balance btwn making and breaking down ecm proteins
secretion of exm degrading proteinases
4 families of ecm degrading proteinases
matrix metalloproteinases
plasminogen activator/plasmin
cathepsins (cysteine proteinases)
adamts
4 kinds of matrix metalloproteinases (mmps_
collagenases
gelatinases
stromelysins
membrane type mmps
wht makes up a mmps?
propeptide---catalystic domain Zn2+____c-terminal domain
mmps properties (4)
secreted in a latent proenzyme form
activated extracellularly
require zinc and calcium for activity
differ in regulation and substrate specificity
regulation of mmp activity- ecm remodeling. 3
enzyme synthesis
enzyme activation
proteinase inhibitors
inhibitors of mmps-4
secreted proteins
bind to mmps
inhibit activity
balance of mmps vs. inhivitors determines net degredation
what aa is involved with plasminogen?
serine
what 2 activators are needed to activate plasminogen?
uPA and tPA
what are phsiological inhibitors of plasminogen
PAIs
what do plasminogens do?
degrade many ecm components, such as collages, fibronectin, proteoglycans
what certain growth factors do plasminogens activate?
TGFbeta and HGF
What are cathepsins- what aa is involved
cysteine proteinases
at what pH are cathepsins most active?
at an acidic pH
what do cathepsins degrade?
ecm components in lysosomes after they are phagocytosed
which kind of cathepsin is found in the ecm?
cathepsin K
what is the role of proteinases in development- 3
cell migration/invasion
neovascularization
chondrogenesis
conditions assoc with abnormal ecm remodeling
arthritis
tumor cell metastasis
tibial dyschondroplasia