GU: Tumors of urinary bladder Flash Cards

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Title: GU: Tumors of urinary bladder
Description: AFIP review material
Number of Cards: 16
Save Count: 1
Author: JMH
Created: 2007-09-10
Tags: bladder genitourinary tumor urinary
Private No

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    • Question
    • Answer
    • Side 3
    • PUNLMP's often progresses to worse lesions with recurrences?
    • NO!!
      - when they do recur, it is typically as a similar lesion
      - rarely are they associated with progression
      - follow-up is indicated however
    • squamous papillomas differ from condyloma accuminatum by ___
    • - a lack of koilocyte atypia and no demonstrable HPV 6/11
    • Deep muscle invasion can be determined on an adequate bladder biopsy?
    • NO! Adipose tissue can be present in the muscularis propria and lamina propria too! Can only determine this on a partial or complete cystectomy specimen.

      - However, do mention the presence or absence of muscularis propria for all bladder biopsies
    • Carcinoma in situ in the bladder must be full-thickness to qualify for this diagnosis?
    • NO! In the bladder, any number of cytologically malignant cells in the non-papillary urothelium is cis!
    • urothelial atypia/dysplasia is used when _
    • - insufficient cytologic atypia to justify a dx of cis
      - used when there is aytpia that is favored to be neoplastic, but just cannot quite make the diagnosis
    • The giant cells in urothelial carcinoma with osteoclastic giant cells are neoplastic??
    • No!
      - believed to be a reaction to the tumor
      - no affect on prognosis
    • urothelial carcioma, clear cell variant is distinguished from clear cell adenocarcinoma morphologically by __
    • - presence of typically papillary or in situ lesions
      - lack of the tubular, microcystic, and hobnail features
    • urothelial carcinoma with ectopic placental glycoprotein production (usually beta-hCG): the hCG immunopositivity differs from that seen in choriocarcinoma by ___
    • - immunoreactivity in urothelial caricnoma is NOT confined to the syncytiotrophoblasti-like giant cells
    • nested variant of urothelial carcinoma can mimic __
    • - von Brunn nest!!
      - however, urothelial carcinioma shows more variation in nest size and contour, and have MILD nuclear atypia
      - at the deeper aspects there is typically greater anaplasia!
    • Adenocarcinoma of the bladder is the tumor type common in ___
    • bladder extrophy
    • The common sarcoma of the bladder in children and adults
    • - children: rhabdomyosarcoma (sarcoma botryoides) in the trigone area

      - adults: leiomysarcoma
    • squamous metaplasia in the trigone of the bladder, similar histologically to the lining of the ___ is common in reproductive age women
    • - nonkeratinized vaginal mucosa; NOT a significant risk factor for caricnoma
      - contrast: leukoplaskia (keratinizing squamous metaplasia IS a significant risk factor for carcinoma; most SCC of the bladder arise from areas of keratinizing squamous metaplasia
    • Papillary-polypoid cystitis resembles cystopically a __
    • - papillary neoplasm
      - not neoplastic; it's an exophytic lesion due to inflammation and edema
    • primarmy amyloidosis of the bladder extensively involves the vessel walls??
    • NO! Not in primary amyloidosis
    • glandular metplasia in the bladder is a risk factor for urothelial carcinoma??
    • NO!
      - EXTENSIVE glandular metaplasia is a risk factor for ADENOcarcinoma!
    • most bladder cysts are of __ origin, and occur in the __
    • - urachal origin
      - anterior wall or dome