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25 Cards in this Set
- Front
- Back
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6 major groups of antidepressants:
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1) cyclic antidepressants (TCA)
2) Selective Serotonin Reuptake Inhibitors (SSRI) 3) Serotonin & Norepinephrine Reuptake Inhibitors (SNRI) 4) Norepinephrine inhibitors (NRI) 5) monoamine oxidase inhibitors (MAOI) 6) atypicals |
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True or False: Tricyclics are considered "dirty drugs" because they react with a number of receptors besides the one responsible for the therapeutic effect.
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True
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True or False: Tricyclics are quite toxic and even a small overdose can be lethal.
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True
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SSRI's drugs:
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Prozac, Zoloft, Paxil, Lexapro
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SNRI's drugs:
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Cymbalta, Effexor, Remeron
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NRI drug:
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Strattera
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Atypical drugs:
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Wellbutrin, BuSpar
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MAOI (monoamine oxidase) drugs:
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nardil, parnate
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Stimulant drugs:
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dexedrine, ritalin
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True or False: It is important to treat remission, not improvement
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True
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True or False: With the possible exception of severe and melancholic depression, all antidepressants have similar efficacy.
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True
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Activation
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the acute onset of side effect seen within the first few hours after starting an antidepressant or when doses are increased. typically lasts only a week or two
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Switching
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occurs when a person being treated with an antidepressant is provoked into a manic state. switching does not occur until after several weeks of treatment
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Treatment resistant depression
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refers to a depression that has failed to respond to adequate trials of two or more antidepressants. As many as 10-20% of people with depression fall into this category.
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3 over the counter products shown to have efficacy in the treatment of depression:
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1) St Johns Wart (do not take with another antidepressant, 1 week washout)
2) SAM-e (s-adenosyl-methionine) 3) Omega-3 fatty acids (unipolar & bipolar depression) |
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True or False: For treating bipolar disorder, pharmacotherapy is unquestionably the mainstay of treatment.
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True
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First-line agents for the treatment of bipolar disorder:
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Lithium & divalproex (Depakote)
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Therapeutic Window
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the therapeutic dose is very close to the toxic dose. (lithium has a very narrow therapeutic window)
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Lithium has an effect on what two neurotransmitters:
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dopamine & norepinephrine
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3 Anticonvulsants:
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1) carbamazepine
2) divalproex 3) lamotrigine |
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atypical antipsychotic:
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Olanzapine
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True or False: Patients with bipolar disorder frequently require multiple medications or changes in therapy
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True
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True or False: antidepressants are a good choice of treatment for bipolar disorder.
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False: they can actually induce rapid cycling
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Patients with bipolar typically face __________ treatment.
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lifelong (long-term)
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Some patients may actually become ______ responsive to mood-stabilizing treatment with repeated with episodes of mania.
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less
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