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62 Cards in this Set
- Front
- Back
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3 parts of coagulation system
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vascular wall
coagulation factors platelets |
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in the first part of coagulation, vascular smooth muscle ___s, endothelial cells ___, and subendothelial ___ causes ___.
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contracts
release factors III, VIII collagen platelet adhesion |
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5 platelet steps in primary hemostasis
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adhesion
shape change to discoid degranulation recruitment aggregation (primary hemostatic plug) |
|
platelets use ___ to adhere to subendothelial ___
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vWF
collagen |
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platelets use ___ to bind vWF, which is secreted by ___ (3).
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GP-Ib
endothelial cells platelets megakaryocytes |
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vWF is a carrier protein for ___ and is aka ___
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factor VIII
factor VIII related Ag |
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vWF circulates as ___ which must be ___ to be functional
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multimers
large |
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2 kinds of platelet granules
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alpha
delta |
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alpha granules contain
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coagulation factors
|
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delta granules are aka ___. they contain ___ (2).
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dense granules
ADP serotonin Ca2+ |
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platelets use the ___ complex to bind ___. this system causes ___.
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GPIIb,IIIa
fibrinogen platelet aggregation |
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___ serves as a binding site for factors ___ (2)
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platelet factor 3
V VIII |
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platelet activation includes ___ activation and ___ (2) production
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PF3
thrombin TXA2 |
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TXA2 causes ___ (3)
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vasoconstriction
platelet degranulation platlet aggregation |
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aspirin inhibits synthesis of ___ (2)
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TXA2
ADP |
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von Willebrand's disease is deficiency in ___
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vWF
|
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Glanzmann's thrombasthenia is deficiency in ___
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GPIIb,IIIa
|
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Bernard-Soulier syndrome is deficiency in ___
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GPIb
|
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factor I is ___
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fibrinogen
|
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factor II is ___
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prothrombin
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factor III is ___
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tissue factor
|
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factor V is ___
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labile factor
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___ causes hemophilia A
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factor VIII
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___ causes hemophilia B
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factor IX
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___ causes hemophilia C
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factor XI
|
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extrinsic pathway
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III
VII |
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intrinsic pathway
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XII
XI IX VIII |
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common pathway
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X
V II I XIII |
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VII activates ___ (2)
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IX
X |
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IX activates ___
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X
|
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PT is ___ and measures ___. it is normally ___.
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prothrombin time
extrinsic + common pathways 12s |
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4 vitamin K dependent factors
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II
VII IX X |
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2 vitamin K dependent regulatory proteins
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protein C
protein S |
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most coagulation factors are ___ proteases
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Ser
|
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during secondary hemostasis, ___ contracts
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intraplatelet actomyosin
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during 2' hemostasis, thrombin activates ____, which causes bridging of ___ at ____. this converts ___ to ___.
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XIII
fibrin D domains soluble fibrin clot stabilized fibrin clot |
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factor XII is activated by ___ (2)
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prekallikrein
high molecular weight kininogen |
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3 anticoagulants produced by endothelium
2 thrombolytics produced by endothelium |
PGI2
heparan sulfate thrombomodulin tPA urokinase |
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PGI2 is aka
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prostacyclin
|
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antithrombin 3 deactivates ___ (5)
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IIa
IXa Xa XIa XIIa |
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PGI2 effects
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vasodilation
conversion of ADP to anti-platelet aggregation factors |
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thrombin, via ___, activates ___. this serves to inactivate ___ (2).
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thrombomodulin
protein C Va VIIIa |
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___ is a cofactor for protein C
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protein S
|
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heparin works by activating ___
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antithrombin 3
|
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antithrombin 3 works fast/slow
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fast
|
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warfarin works by ___
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inhibiting gamma-carboxylation of vitamin K dependent factors
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warfarin works fast/slow
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slow (3-5 days)
|
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urokinase is produced by ___ (2)
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endothelium
monocytes |
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thrombolytics cause ___ (2) and inhibit ___ (3)
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activation of plasminogen
cleavage of fibrin and fibrinogen platelet aggregation thrombin activity fibrin cross-linking |
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3 products of plasmin clot degradation
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D-dimers
E fragments DED complex |
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vessel abnormalities have ___ bleeding time, ___ platelet count, ___ PT and ___ aPTT
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normal
normal normal normal |
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hemophilia A has ___ bleeding time, ___ platelet count, ___ PT, and ___ aPTT.
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normal
normal normal high |
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hemophilia A is due to ___ deficiency. a common cause is ___ but it can be inherited as ___ trait.
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factor VIII
spontaneous mutation XLR |
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hemophilia A is treated with ___
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factor VIII, IX concentrate
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hemophilia A commonly presents with ___
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hemarthrosis
|
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hemophilia B is ___ deficiency
its inheritance is ___ it is also called ___ |
factor IX
XLR Christmas disease |
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___ is the most common hereditary coagulation disease
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von Willebrand Disease
|
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VWD has ___ bleeding time, ___ platelet count, ___ PT, and ___ aPTT.
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increased
normal normal normal/increased |
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vitamin K deficiency has ___ bleeding time, ___ platelet count, ___ PT, and ___ aPTT
|
normal
normal increased normal/increased |
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factors synthesized in liver (6)
|
I
II V VII IX X |
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severe liver disease has ___ bleeding time, ___ platelet count, ___ PT, and ___ aPTT
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normal
normal high high |
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in thrombocytopenia bleeding time is ___, PT is ___, aPTT is ___.
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normal/high
normal normal |
