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26 Cards in this Set
- Front
- Back
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What does heparin do?
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Heparin facilitates the action of antithrombin III
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What does antithrombin III do?
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Antithrombin III inactivates thrombin, Factor IXa, and Factor Xa
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Reversal of heparin toxicity
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Protamine Sulfate reverses heparin overdose
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Enoxaparin
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Enoxaparin- low molecular weight heparin
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Dalteparin
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Dalteparin- low molecular weight heparin
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Fondaparinux
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Fondaparinux- heparin analogue that only inhibits Factor Xa
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Coagulation proteins that require Vitamin K to function
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Prothrombin, Factor VII, Factor IX, Factor X, Protein C, Protein S all require Vitamin K to function
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Warfarin
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Warfarin inhibits Vitamin K Epoxide Reductase
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Administration of Warfarin
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Warfarin is orally active
Contraindication- pregnant women |
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Lepirudin
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Lepirudin is a direct thrombin inhibitor
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Dabigatran
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Dabigatran is a direct thrombin inhibitor
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Advantages and clinical use of Dabigatran
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Dabigatran is an orally active thrombin inhibitor that is indicated to prevent thrombi in atrial fibrillation patients.
Advantages: orally active, don't have to monitor blood |
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Bivalirudin
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Bivalirudin- direct thrombin inhibitor
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Argatroban
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Argatroban- direct thrombin inhibitor
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MOA of fibrinolytic drugs
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Fibrinolytic drugs facilitate the formation of Plasmin from Plasminogen, which dissolves the fibrin in clots
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Clinical indication for fibrinolytic drugs
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Fibrinolytic drugs are used to treat arterial thrombi
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Streptokinase
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Streptokinase- fibrinolytic drug (drives Plasminogen --> Plasmin)
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Alteplase
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Alteplase- recombinant tPA (fibrinolytic drug that drives Plasminogen --> Plasmin)
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Aspirin
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Aspirin inhibits cyclooxygenase, which prevents formation of TxA2 (thromboxane)
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Clopidogrel
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Clopidogrel blocks ADP receptor, thereby inhibiting GPIIa/IIIb expression
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Abciximab
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Abciximab is a monoclonal antibody that blocks GPIIa/IIIb on platelets
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Eptifibatide
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Eptifibatide blocks GPIIa/IIIb on platelets
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Tirofiban
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Tirofiban blocks GPIIa/IIIb on platelets
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Cilostazal
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Cilostazal blocks phosphodiesterase III thereby preventing platelet aggregation
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Drugs to prevent MI
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Drugs to prevent MI:
Aspirin, Abciximab, Eptifibatide, Tirofiban, Clopidogrel |
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Drugs to prevent TIA and stroke
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Drugs to prevent TIA and stroke: aspirin, clopidogrel
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