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What is the critical enzyme for te secondary hemostasis process?
thrombin
What is the schematic of the clotting cascade?
Platelets come in contact with ta vessel. extrinsic cascade is short-lived: Factor 7 is activated by TF (on collagen on subendothelium. Intrinsic cascade: F7/TF complex activates F9 and F10, which make up the throminse complex in the presence of platelets and calcium. They transform prothrombin into thrombin (active), which causes fibrin to eventually be cross-lnked and deposited on top of the platelets.
What is the one of the most common causes of secondary hemostasis disorders?
liver disease - jaundice, ascites, spider telangiectasias

also warfarin anticoagulation
WHat's the most common cause of cirrhosis in this country?
Hep C. Not alcohol!
What is the normal range for INR?
2-3
Besides INR, what can lead to an increased risk of bleeding?
warfarin, stroke, GI bleed, age>65 years`
What is the treatment for DIC?
Treat hte underlying cause
What is DIC an abnormal response to?
Thrombotic disorder that's an abnormal response to infection, pregnancy, tumor tat uses up platelets and coagulation factors.
What's the best method of diagnosis of a genetic deficiency of a coag factor?
A history of hematoma and hemarthrosis can diagnose Hemophilia A (8) and B (9)
What is severe hemophilia
< 1% F8 or F9
What is the critical enzyme for te secondary hemostasis process?
thrombin
What is the schematic of the clotting cascade?
Platelets come in contact with ta vessel. extrinsic cascade is short-lived: Factor 7 is activated by TF (on collagen on subendothelium. Intrinsic cascade: F7/TF complex activates F9 and F10, which make up the throminse complex in the presence of platelets and calcium. They transform prothrombin into thrombin (active), which causes fibrin to eventually be cross-lnked and deposited on top of the platelets.
What is the one of the most common causes of secondary hemostasis disorders?
liver disease - jaundice, ascites, spider telangiectasias

also warfarin anticoagulation
WHat's the most common cause of cirrhosis in this country?
Hep C. Not alcohol!
What is the normal range for INR?
2-3
Besides INR, what can lead to an increased risk of bleeding?
warfarin, stroke, GI bleed, age>65 years`
What is the treatment for DIC?
Treat hte underlying cause
What is DIC an abnormal response to?
Thrombotic disorder that's an abnormal response to infection, pregnancy, tumor tat uses up platelets and coagulation factors.
What's the best method of diagnosis of a genetic deficiency of a coag factor?
A history of hematoma and hemarthrosis can diagnose Hemophilia A (8) and B (9)
What is severe hemophilia
< 1% F8 or F9; lifelong spontaneous bleeds
What is the critical enzyme for te secondary hemostasis process?
thrombin
What is the schematic of the clotting cascade?
Platelets come in contact with ta vessel. extrinsic cascade is short-lived: Factor 7 is activated by TF (on collagen on subendothelium. Intrinsic cascade: F7/TF complex activates F9 and F10, which make up the throminse complex in the presence of platelets and calcium. They transform prothrombin into thrombin (active), which causes fibrin to eventually be cross-lnked and deposited on top of the platelets.
What is the one of the most common causes of secondary hemostasis disorders?
liver disease - jaundice, ascites, spider telangiectasias

also warfarin anticoagulation
WHat's the most common cause of cirrhosis in this country?
Hep C. Not alcohol!
What is the normal range for INR?
2-3
Besides INR, what can lead to an increased risk of bleeding?
warfarin, stroke, GI bleed, age>65 years`
What is the treatment for DIC?
Treat hte underlying cause
What is DIC an abnormal response to?
Thrombotic disorder that's an abnormal response to infection, pregnancy, tumor tat uses up platelets and coagulation factors.
What's the best method of diagnosis of a genetic deficiency of a coag factor?
A history of hematoma and hemarthrosis can diagnose Hemophilia A (8) and B (9)
What is severe hemophilia
< 1% F8 or F9; lifelong spontaneous bleeds
What is the critical enzyme for te secondary hemostasis process?
thrombin
What is the schematic of the clotting cascade?
Platelets come in contact with ta vessel. extrinsic cascade is short-lived: Factor 7 is activated by TF (on collagen on subendothelium. Intrinsic cascade: F7/TF complex activates F9 and F10, which make up the throminse complex in the presence of platelets and calcium. They transform prothrombin into thrombin (active), which causes fibrin to eventually be cross-lnked and deposited on top of the platelets.
What is the one of the most common causes of secondary hemostasis disorders?
liver disease - jaundice, ascites, spider telangiectasias

also warfarin anticoagulation
WHat's the most common cause of cirrhosis in this country?
Hep C. Not alcohol!
What is the normal range for INR?
2-3
Besides INR, what can lead to an increased risk of bleeding?
warfarin, stroke, GI bleed, age>65 years`
What is the treatment for DIC?
Treat hte underlying cause
What is DIC an abnormal response to?
Thrombotic disorder that's an abnormal response to infection, pregnancy, tumor tat uses up platelets and coagulation factors.
What's the best method of diagnosis of a genetic deficiency of a coag factor?
A history of hematoma and hemarthrosis can diagnose Hemophilia A (8) and B (9)
What is severe hemophilia
< 1% F8 or F9; lifelong spontaneous bleeds
What is the process in which a platelet plug is formed?
1) Platelets adhere to subendothelium through Gp1b/9a receptor and vWF (subend)
2) Platelets are activated and release granular contents to recruit more platelets
3) Platelet aggregation through fibrinogen receptor
4) Platelet plug - end of primary hemostasis
HOw is thrombocytopenia manifest?
Primary hemostasis - Purpura, petechiae, mucocutaneous bleeding
Whst are 2 causes of dysfunctional platelets in primary hemostasis?
1) renal dysfunction

2) aspirin (irreversible), NSAIDs
What are 2 functions of fibrinogen?
1) Platelet aggregation (primary hemostasis) through fibrinogen receptor (Gp2b/3a)

2) substrate for fibrinogen - formation of fibrin clot
What are 2 functions of vWF?
1) carrier for F8

2) Bridges platelets with subendothelium, activating platelets