- Shuffle
Toggle OnToggle Off
- Alphabetize
Toggle OnToggle Off
- Front First
Toggle OnToggle Off
- Both Sides
Toggle OnToggle Off
Front
How to study your flashcards.
Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key
Up/Down arrow keys: Flip the card between the front and back.down keyup key
H key: Show hint (3rd side).h key
PLAY BUTTON
PLAY BUTTON
6 Cards in this Set
- Front
- Back
|
what are 2 general types of mutations we see in Hb?
|
Qualitative - Hb varrients
Quantitative - Basically no Hb is produced. |
|
What are potential functional properties of hemoglobin variants?
|
Increased O2 affinity
Decreased O2 affinity Creation of Unstable Variants Methemoglobinemia - where Fe2+ is oxidized to Fe3+. |
|
What is the result of Beta + Thalassemia?
What is the result of Beta naught Thalassemia? |
Beta + - decreased production of beta globin chains from the affected gene
Beta naught - absence of beta chain production completely. |
|
what happens when you have heterozygosity for B naught or B plus gene?
|
-clinically asymptomatic
-mild anemia in some cases -have elevated HbA2, -have elevated HbF (1 to 5%) |
|
what are the problems that arise when the pt is a homozygote for B naught or B plus
|
-dependent on blood transfusions
-hepatosplenomegaly, growth retardation, delayed puberty, bony abnormalities, -iron overload (i think caused by lots of blood transfusion) -> get bone marrow expansion and increaseed iron absorbtion in the gut. |
|
what happens in sickle cell anemia? what is the change?
|
the beta chain of the hemoglobin contains a valine rahter than a glutamate at position 6. this replaces an amino acid with a negative charge.
this allows the deoxygenated molecules of HbS to polymerize and can thus assume the sickle shape. these cells undergo hemolysis and an anemia results. |
