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7 Cards in this Set
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Serine Proteases when activated:
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IIa, VIIa, IXa, Xa, XIa, XIIa, Prekallikrein
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Cofactors:
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V, VIII, HMWK, Tissue Factor (binds to a particular serine protease)
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Substrate:
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I (Fibrinogen)
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Transglutaminase:
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XIIIa
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Fibrinogen Group
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I, V, VIII, XIII
o Consumed in clot o Acted upon by thrombin |
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Contact Group
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XII, XI, PK, HMWK
o XII, PK, HMWK important for in vitro activation in the "intrinsic pathway" ONLY o Activation of XII, PK and HMWK is NOT important for initiation of clotting in vivo o Deficiencies of XII, PK, or HMWK are asymptomatic; they do not result in bleeding symptoms |
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Prothrombin Group
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II, VII, IX, X, Protein C Protein S
-These factors require Vitamin K to be functional -synthesized by the liver -inhibited by Warfarin |
