Hemostasis Questions

The coagulation Common pathway consists of:
A.) factors II, VII, IX, and XI
B.) XII, XI, XIII and IV
C.) III, vWF, Ca2+, and prothrombin
D.) II, V, and X

Tissue thromboplastin (tissue factor) activates the coagulation system. The primary factor that tissue thromboplastin activates is:
A.) I
B.) XIII
C.) VII
D.) VIII
E.) XII

von Willebrand's factor is:
A.) LMW and called VIIIC:Ag
B.) HMW and called VIIIR:Rco
C.) HMW and called VIIIC
D.) LMW and called VIIIR:Ag

The Vitamin K dependent factors are:
A.) II, XII, IX, XIII, protein C, thrombomodulin
B.) VII, V, IX, X, protein C, protein S
C.) I, VI, IX, X, protein C, protein S
D.) II, VII, IX, X, protein C, protein S

vonWillebrand factor is the carrier protein for coagulation factor:
A.) VII
B.) V
C.) VIII
D.) IX

For the majority of coagulation proteins, an acitivity level of ____% is all that is necessary for hemostasis.
A.) 10-15
B.) 25-30
C.) 45-55
D.) 75-85

Protein C along with it's Cofactor Protein S cleave factor:
A.) XIIIa
B.) IXa
C.) Va
D.) VIIa

Protein C depends upon two of the following in order to become activated.
A.) Thrombomodulin
B.) Thromboxane A2
C.) Factor Xa
D.) Factor IIa (thrombin)
E.) Prostacyclin
F.) alpha-2 antitrypsin

Converts fibrinogen to fibrin

Crosslinks fibrin multimers to form a stabilized clot

Factor Xa and its cofactor ____convert prothrombin to thrombin

Antihemophilia A factor

Antihemophilia B factor

Which of the follwoing is an example of an acquired platelet disorder?
A.) Uremia
B.) Bernard-Soulier syndrome
C.) Storage pool deficit
D.) vW disease
E.) May-Hegglin anomaly

Thrombotic thrombocytopenia purpura (TTP) quantitative or qualitative

Uremia

Glanzman's Thrombasthenia

aplastic anemia

immune thrombocytopenia purpura (ITP)

A 3 year old presents with severe thrombocytopenia following a bout of bloody diarrhea caused by E. coli 0157:H7. The most likely disorder is:
A.) cirrhosis
B.) lupus erythematosis
C.) vonWillebrand's disease
D.) TTP
E.) ITP

This disease has multiple presentations: In children more boys than girls are affected, in adults more women than men are affected. In children the best treatment is no treatment while in adults, corticosteroids are often effective, RhIg may also be utilized in some adults. The disease that best fits this description is:
F.) DIC
G.) ITP
H.) HUS
I.) TTP
J.) HITT