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11 Cards in this Set

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Hepatitis A
- Picornavirus
- + SS RNA
- no envelope
- enteric transmission
- no chronicity
Hepatitis B
- Hepadnavirus
- Partially DS DNA
- has an envelope
- Parenteral transmission
- establishes chronic infection
Hepatitis C
- Flavivirus
- + SS RNA
- has an envelope
- parenteral transmission
- establishes chronic infections
transmission of hepatitis viruses
A - fecal-oral/contaminated food
B - US: sexual, IV drug users; Worldwide, Maternal-fetal
C - IV drug users
Replication of Hep A
- produces and cleaves a large polyprotein
- cytoplasmic RNA to RNA replication by a virally encoded polymerase
- Released from cells by cytolysis
HBsAgs
- Hep B particles
- Heb B produces 1000x excess of non-infectious subviral particles composed of cellular lipids and viral surface glycoproteins.
chronic infection with Hep B
- 90% neonates
- 5% adults
- 40% male chronic carriers die
Hepatitis D
- viroid-like defective virus
- encodes 1 protein, delta antigen
- must be concurrent with HBV, provides envelope
- RNA to RNA replication by host RNA pol II
Hep C features
- flavivirus similar to yellow fever virus
- uncapped, non-polyadenylated single stranded + polarty RNA
- encodes large polyprotein
HCV replication
- viral RNA translated independently of cap to make polyprotein
- replicated in cytoplasm by viral RNA-dependent RNA polymerase
- new viruses released w/o killing cell
Hep E
- Non-enveloped, environmentally stable virion
- first member of Hepeviruses
- + polarity RNA
- single-stranded
- 3 ORFs
- can cause massive epidemics
- highly fatal in pregnancy.