HIS17 Adaptive Immunity Flash Cards

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- Produces antibodies
- B-cells
- CD4+
- Cytokine production (T helper cells)
- CD8+
- Cytotoxic T cells (CTL)
- Occurs after maturation of the B-cells, once migrated to periphery, introduction of mutations in the V regions of rearranged antibody
- Somatic Hypermutation
- Produce cytokines and interact with cells to promote their activation
- Th (T helper cell)
- Activated to kill infected cells
- Tc (Cytotoxic T-cell)
- Only recognise peptide antigen bound to MHC
- T cell receptor
- Multiple germline segments to generate diversity in the TcR
- Combinatorial Diversity
- Addition of non-template encoded (N) and palindromic (P) nucleotides at imprecise joints made between V-D-J elements to generate diversity in the TcR
- Junctional Diversity
- Is somatic mutation used to generate diversity in TcR?
- NO!!!!!!!!!!
- Immature B cells that express high affinity 'self' receptors, these either die, receive antibody editing (mutation) or have long term inactivation
- Negative selection
- Dependent on the stromal cells in the bone marrow
- B cell development
- Thymus provides environment for maturation
- T cell development