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21 Cards in this Set

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  • Back
What is the mechanism of sodium oxybate?
Stimulates GABAb and GHB specific receptors --> restores sleep, treats cataplexy a/w nacolepsy
Which class of drugs is most likely to precipitate acute intermittent porphyria in a genetically predisposed individual?
Barbiturates
Which drugs put you to sleep but don't keep you asleep?
Ramelteon, Triazolam, Estazolam
Which antidepressant is most likely to produce weight gain?
TCA (amitryptyline)
Which antidepressant is least likely to produce weight gain?
Buproprion
Which antidepressant is most likely to produce N/V?
Fluoxetine (SSRI)
Antipsychotic drugs carry black box warning for management of what condition in elderly?
Alzheimer's
What is the basis of tardive dyskinesia in antipsychotics?
High D2 potency drugs --> uprgulation of D2 receptors
Which antidepressant is most likely to produce orthostatic hypotension?
TCA (amitriptyline)
Which antidepressants are most likely to produce pharmacokinetic interactions due to inhibition of cyp450?
SSRIs (Fluoxetine)
Which BZDs have no active metabolites?
TOLE
Temazepam, Oxazepam, Lorazepam, Estazolam
Which BDZ has the shortest duration of effect?
Triazolam
What is the important AE of ramelteon?
hyperprolactinemia
Which drugs have cross-dependence with EtOH?
Barbs, Benzos, Opioids
What is unique about the met of phenobarbitol and paraldehyde?
phenobarb --> 30% renal excretion
paraldehyde --> 10-30% pulmonary
Which SSRI has biggest problem with motor restlessness?
fluoxetine and sertraline
Which antidepressants have the greatest degree of antimuscarinic effects?
TCAs (Amitriptyline)
Which antipsychotics have high potential of tardive dyskinesia?
high D2 potency typicals --> haloperidol
Which antidepressant is used to manage insomnia?
Trazodone (5HT2a and SERT inhibition)
Which SSRI takes longest to clear from the body?
Fluoxetine (180)
Sertraline (80)
Which drugs are used most frequently to manage anxiety?
SSRI (fluoxetine) --> Rx panic attack and GAD

Alt. Buspirone --> slow onset, no dependance