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21 Cards in this Set
- Front
- Back
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MOA - lovastatin
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inhibits HMG CoA reductase in liver
up regulates LDL receptor on liver |
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MOA - cholestyramine
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blocks recycling of bile salts
increases livers need for cholesterol up regulates LDL receptor |
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MOA - ezetimibe
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inhibits cholesterol absorption from intestine
liver needs cholesterol from another source than diet up regulates LDL receptor |
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MOA - niacin
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Decreases VLDL synthesis (main)
Increases VLDL catabolism |
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MOA - fenofibrate
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Increases VLDL catabolism (main)
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Effect of simvastatin on LDL and TG (small, moderate, large increase or decrease)
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large decrease LDL
moderate decrease TG |
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Effect of cholestyramine on LDL and TG (small, moderate, large increase or decrease)
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moderate decrease LDL
transient increase TG |
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Effect of ezetimibe on LDL and TG (small, moderate, large increase or decrease)
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moderate decrease LDL
small decrease TG |
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Effect of niacin on LDL and TG (small, moderate, large increase or decrease)
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moderate decrease LDL
large decrease TG |
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Effect of gemfibrozil on LDL and TG (small, moderate, large increase or decrease)
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small decrease or increase LDL
large decrease TG |
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which drug has the highest effect on raising HDL?
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niacin
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Side effect - myopathy and rhabdomyolysis
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statins
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Side effect - flushing
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niacin
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Side effect - hepatotoxicty and hyperuricemia?
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niacin
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Side effect - hepatotoxity
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statins and niacin
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Side effect - Constipation, nausea, heartburn, bloating, abdominal pain, impaired absorption of anionic drugs
and fat soluble vitamins |
bile acid binding resins
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Which of the following combinations will increase your risk of myopathy
Statin + cholestyramine Statin + ezetimibe Statin + gemfibrozil |
Statin + gemfibrozil
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What effect will statins and cholestyramine have on HMG CoA reductase?
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statin - block activity
cholestyramine - up regulate activity |
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Which class of drugs will cause the greatest lowering of LDL?
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statins
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Which class of drugs will cause the greatest lowering of TG?
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niacin and gemfibrozil
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Which will lower TG better?
gemfibrozil or cholestyramine |
gemfibrozil
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