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30 Cards in this Set
- Front
- Back
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Salmonella:
- Stain - Shape - Metabolism |
Gram negative
Rod shaped Faculative anaerobes |
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Salmonella:
- Species |
S. enterica
|
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Salmonella:
- Clinical syndromes |
Localized gastroenteritis
Enteric (typhoid) fever Bacteremia and vascular infection |
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What strains of salmonella cause localized gastroenteritis?
|
S. enteriditis
S. typhimurium |
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What are the symptoms of localized gastroenteritis?
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Nausea
Vomiting Fever Loose stools with inflammatory cells |
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What strains of salmonella cause enteric (typhoid) fever?
|
S. typhi
S. paratyphi |
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What are the symptoms of typhoid fever?
|
Sever systemic infection
FEver Abdominal symptoms |
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What strains of salmonella cause sustained bacteremia and vascular infection?
|
S. choleraesuis
S. dublin |
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Salmonella:
- Encounter |
Fecal oral route from infected human
|
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Salmonella:
- Colonization |
Ivasion across gut epithelium (type III secretion apparatus)
|
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Salmonella:
- Damage |
Robust inflammatory response
Reiter's syndrome (arthritis of joints) |
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Salmonella:
- Spread |
S. typhi and S. paratyphi grow well in macrophages
|
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Salmonella:
- Resistance |
Colonize gallbladder to promote carrier state
|
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Salmonella:
- Treatment |
Antibiotic therapy
|
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Salmonella:
- Prevention |
Vaccination against typhoid
|
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Shigella:
- Stain - Shape - Metabolism |
Gram negative
Rod shaped Lactose non-fermenters |
|
What are the four groups of Shigella?
|
S. sonnei (most important in developed countries)
S. flexneri S. boydii S. dysenteriae (most virulent) |
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Shigella:
- Encounter |
Person to person
|
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Shigella:
- Resistance |
Resistant to stomach acid
|
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Shigella:
- Areas of colonization |
Small intestine
Descends to colon Self-limiting to mucosa |
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Shigella:
- Symptoms |
Fever
Cramping Voluminous watery diarrhea Frequent defecation |
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What is the only strain of Shigella to produce shiga toxin?
|
S. dysenteriae
|
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What does shiga toxin do?
|
A-B toxin that inactivates ribosomal RNA, blocking protein synthesis
HUS |
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Shigella:
- Diagnosis |
Descending intestinal infection
Organisms die quickly in stool samples |
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Shigella:
- Treatment |
Fluid replacement
AB treatment |
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Listeria monocytogenes
- Stain - Shape - Metabolism |
Gram positive
Rod shaped |
|
Listeria monocytogenes
- Encounter |
Orally
Dairy products |
|
Listeria monocytogenes
- Resistance |
Uptake by gut epithelium via macrophages and survival inside cells
|
|
Listeria monocytogenes
- Damage |
Septicemia
Meningitis |
|
Listeria monocytogenes
- Clinical syndromes |
Pregnancy
- Precipitate labor Neonates / Immunosuppressed adults - 100x higher risk in AIDS patients - Sepsis - Meningitis, cerebritis |
