• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

image

PLAY BUTTON

image

PLAY BUTTON

image

Progress

1/21

Click to flip

Card Range To Study

through

21 Cards in this Set

  • Front
  • Back
Non-Hodgkins lymphoma
Lymphocyte cancer
Acute lymphoblastic leukemia (ALL)
Children
(lymphoid) Bone marrow and blood
Rapid increase immature lymphocytes
Pre-B cell leukemia
(pre-B) Bone marrow and blood,
Chronic lymphocytic leukemia (CLL)
(activated/ memory B cell, adults)
(B1 postnatal, CD5 = self-renewal from cytokine IL-10)
B1: diverse V repertoire, rearranged immunoglob N nucleotides
Follicular cell lymphoma
(mature, memory B)
Mature B cells tumors grow in follicle of lymph nodes
Non-Hodgkins lymphoma
Rituximab: monoclonal antibody treatment: anti-CD20 antigen
Reed-Sternberg cells
No antigen receptor b/c somatic mutation
Strange dendritic morphology
Multiple myeloma
Plasma cell tumor in bone marrow
Multiple myeloma
Secrete monoclonal antibody (IgA/IgG)
Synth more light chain than heavy
Multiple myeloma
Migrate and erode calcification, anemia/ neutropenia
Hodgkin’s lymphoma
(germinal center) peripheral circulation = mutated immunoglob.
Hodgkin’s lymphoma
Spleen/ lymph node/ bone marrow/ organs, 1st radiotherapy success
Hodgkin’s lymphoma
Cancer involved with Reed-Sternberg cells
Epstein-Barr virus
Chronic infected B cells divide repeatedly
Epstein-Barr virus
Mutate to Burkitt’s
(MYC gene regulates cell cycle but mutated Ig gene transformation and translocation)
Burkitt’s lymphoma
(like germinal center B cell)
Burkitt’s lymphoma
latent infection, dsDNA Herpes
infected as adolescent= mononucleosis
Burkitt’s lymphoma
EBNA-1 escapes effective proteosome processing (do not bind MHC I)
Burkitt’s lymphoma
MYC proto-oncogene on chromo 8 (regulates cell cycle) joined by translocation to immunoglob heavy chromo 14 or light chromo 22
Acute lymphoblastic leukemia (ALL)
Prevent production of other hematopoietic cells
No functional Ig
Chronic Lymphocytic Leukemia (CLL)
slow mutation Ig depend on time of mutagenesis
Possible Association with Herbicides in Vietnam