• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

image

PLAY BUTTON

image

PLAY BUTTON

image

Progress

1/16

Click to flip

Card Range To Study

through

16 Cards in this Set

  • Front
  • Back
What are the 3 pathways of complement activation?
1. The Classical Pathway - triggered by antibodies that bind pathogens

2. The Alternative Pathway - antibody independent pathway in which complement activation is amplified on microbial surfaces

3. The Mannose Binding Lectin Pathway - Antibody independent, recognizes a microbial surface feature
What are the 3 major functions of complement?
1. Opzonization and phagocytocis

2. Stimulation of inflammatory reactions

3. Complement-mediated cytolysis
What is the common complement effector molecule used by all 3 complement pathways?
C3b
Will soluble IgM/IgG or Antigen Bound IgM/IgG cause complement activation?
Antigen Bound
What activates the Alternative Pathway?
C3b binding directly to microbial cell walls
What activates the Classical Pathway?
C1 binding to antigen-antibody complexes
What does C1 bind to?
2 adjacent IgG antibodies that are bound to microbial surface
What do complement proteins create on the membrane of a microbe that allows for cytolysis?
The Membrane Attack Complex (MAC) which creates pore in membrane that causes microbe to lyse
What type of bond links C3 fragments to bacteria surface proteins and sugars?
Thioester mediated covalent bond
What are the 3 categories of complement regulatory proteins?
1. C1 inhibition - C1INH

2. Proteins that inhibit C3 convertase (DAF)

3. Proteins that inhibit the MAC (CD59 and plasma s protein)
What molecule inhibits C1?
C1INH
What inhibits C3 convertase?
DAF (Decay Accelerating Factor) that is present on normal cells
What protein inhibits MAC formation on normal cells?
CD59 and plasma S protein
Absence of functional DAF will give what condition?
Paroxysmal nocturnal hemoglobinuria (wake up at night and pee blood)
Deficiency in C1INH is associated with what disease?
Angioneurotic Edema
Deficiency of CD59 leads to what?
Hemolytic anemia and strokes