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36 Cards in this Set
- Front
- Back
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Antibody structure and function
Which part of the light and heavy chain recognizes the antigen? |
Variable part
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The interchain and intrachain bonds in the antibody are of what type?
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Disulfide bonds
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What is the term called when the antibody prevents bacterial adherence?
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Neutralization
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The amino terminal is part of which fragment of the antibody?
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Fab fragment
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The fab fragment of the antibody is composed of which chain(s)?
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Light and heavy chains
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Describe the Fc fraction of the B cell receptor.
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Constant, Carboxy terminal, Complement-binding (IgG + IgM only), Carbohydrate side chains
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What is the purpose of opsonization?
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The antibody promotes phagocytosis
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The hypervarible region is a compontent of which fragment of the antibody?
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Fab fragment
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Only the heavy chain contributes to which fraction of the antibody?
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Fc
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Why does an antibody activate complement?
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To enhance opsonization and lysis
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The constant part of the heavy chain of IgM and IgG does what?
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Fixes complement
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Which isotype has an unclear function?
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IgD
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What is the main anitbody in a second response to an antigen?
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IgG
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When is IgM produced?
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Primary response to an antigen
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Which isotype induces the release of mediators from mast cells and basophils when exposed to an antigen?
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IgE
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Where is IgD found?
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On the surface of many B cells and in serum
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Which isotype fixes complement, crosses the placenta, opsonizes bacteria, and neutralizes bacterial toxins and viruses ?
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IgG
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Which isotype that guards the mucous membranes from attachement of bacteria and viruses?
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IgA
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IgE stimulates which type of hypersensitivity reaction?
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Type I
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IgE mediates immunity to what?
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Worms
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Which isotype fixes complement but does not cross the placenta?
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IgM
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Which isotype has the lowest concentration in the serum?
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IgE
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Which isotype found in secretions?
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IgA
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Which isotype crosses the placenta?
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IgG
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Which Ig epitope is common to a single class of Ig (5 classes, determined by the heavy chain)?
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Isotype (IgG, IgA, IgM, IgE, IgD) Isotype=iso (same). Common to same class.
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Which Ig epitope is determined by antigen-binding site?
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Idiotype (specific for a given antigen) Idiotype=idio (unique). Hypervariable region is unique.
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Which Ig epitope differs among members of the same species and can be on the light or heavy chain?
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Allotype (polymorphism)
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Antigen presenting cells have which type(s) of MHC protein?
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MHC I and MHC II
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Which class MHC proteins is the main determinants of organ rejection?
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MHC II
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How many class I genes does the MHC consist of?
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3 (A, B, C)
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What class of MHC antigen loading occurs in acidified endosomes?
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MHC II
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All nucleated cells have which type of MHC protein(s)?
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MHC I
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Which class MHC protein has 1 polypeptide with beta 2 microglobin?
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MHC I
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Where does MHC I antigen loading occur in the cell?
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RER (viral antigens)
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What are the 3 MHC II genes?
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DP, DQ, DR
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Which class MHC protein has 2 polypeptides and and alpha and beta chain?
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MHC II
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