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6 Cards in this Set
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Antibodies: Basic Structure?
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Monomeric unit:
- 2 identical light chains covalently linked to 2 identical heavy chains. Each light and heavy chain has a Variable region (N-terminal) & a Constant Region (C-Terminal) |
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How many Monomeric units can exsit?
Which are composed of how many? |
Dimeric, trimeric, pentameric Forms of immunoglobulins.
2, 3, 5 monomeric units respectively. |
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Antibodies are also know as?
Which are? |
Immunoglobulins.
Heterogeneous bifunctional Gylcoproteins secreted by differentiated B cells, termed plasma cells. |
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Light chains Constant regions have how many classes?
What are they? Which is the predominant one? |
2 Classes.
Kappa & Lamda Kappa is predominant. Lambda is there too. But mostly Kappa in the poplulation. |
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Heavy chains has how many Classes?
How are they distiguished? |
-5 major Classes:
-distinguished by differing Constant Alpha (α), Delta (δ), Epsilon (ε), Gamma (γ), Mu (μ). which gives rise to antibody isotypes: IgA, IgD, IgE, IgG and IgM. |
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Heavy Chain Constant Regions give rise to Antibody Isotypes:
What are they? |
IgA, IgD, IgE, IgG and IgM.
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