Immunology Interleukins and CD Receptors

Produced by monocytes and macrophages to activate T cells, induce fever and acute phase response proteins via hepatocytes

Secreted by Th1 (with INFg) to activate T cell proliferation and Treg maintenance

Secreted by thymic epithelial cells and T cells to work with IL5 and GM-CSF in hematopoiesis and cell proliferation via HSCs, NK cells, LAK cells

Secreted by Th2 (with IL5 and IL13) and by mast cells to induce Ig class switching and B cell proliferation

Secreted by Th2 (with IL4 and IL13) and by mast cells to induce eosinophil hematopoiesis and increase IgG1 production

Secreted by T cells, macrophages and endothelial cells to induce B cell growth, differentiation and Ig secretion. It also indirectly induces acute phase responses proteins. IL6 promotes inflammation and Th17 responses.

Secreted by bone marrow and thymic stroma to causes preB cell and preT cell proliferation and naive T cell maintenance

Secreted by Th1 and cytotoxic T cells (with IL2) to activate cytotoxic T cells, macrophages and NK cells by increasing MHC expression. Also has direct antimicrobial activity

Secreted by Treg cells to down regulate activation of other T cells

Secreted by Th2, Treg cells, B cells, and macrophages to inhibit NK cells and macrophage function by decreasing cytokine production- and inhibit Th1 cytokines

Located on B cells. Stimulated by CD40 ligand on Th2 cells to activate Ig class switching.

Secreted by dendritic cells to initiate an adaptive immune response and causes Th1 cell polarization

Short-acting signals produced by immune system cells involved in cell migration and spatial organization of the immune system.

Short-acting autocrine and paracrine hormones produced by immune system cells to regulate immune function

Secreted by Th2 with IL4 and IL5 to help in the antibody-mediated response

Secreted by Th17 with IL23 to play a role in mucosal, skin, and parasite immunity. Also key player in autoimmunity and tissue destruction

Produced by dendritic cells to cause general antiviral and anti proliferative action in somatic cells and initiate an adaptive immune response by serving as the third signal in T cell activation

Secreted by monocytes and T cells to stimulate myelomonocytic precursors and dendritic cells in bone marrow to differentiate into granulocytes and monocytes

Secreted by monocytes and fibroblasts to generally stimulate bone marrow to produce more neutrophils via granulocytes and precursor cells

Produced by CD4 T cells and monocytes to inhibit macrophage activation via T cells and generally inhibit cell growth. Also TGFb stimulates Treg and Th17 differentiation.

Secreted by macrophages, NK cells, and T cells to cause local inflammation, endothelial cell activation and part of the acute phase response

Secreted by Th17 with IL17 to play a role in mucosal, skin, and parasite immunity. Also key player in autoimmunity and tissue destruction. Can activate granulocytes which can be hepatotoxic.