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24 Cards in this Set
- Front
- Back
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Ingestion of a raw potato delivers a new vaccine protein to elicit an immune response. The immune structure to interact with the vaccine protein?
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Lamina propria mucosae
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Inflammation and the resulting increase in vascular permeability permit leakage into damaged or infected sites are effected by
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Phagocytic cells and acute phase proteins
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A 3-year-old boy with genetic C3 deficiency has recurrent ear and lung infections due to pyogenic bacteria. Deficiency of what?
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B lymphocytes
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Treatment with which protease enzyme causes decrease in avidity of IgG w/o changing the specificity of the antibody?
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Papain
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Cells activated by both gamma-IFN and CD40 are
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Macrophages
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The MHC class I pathway presents an antigen directly to what?
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CD8+ T lymphocytes
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HSV infection can block the transfer of antigenic peptides from the cytoplasm to the ER of the infected cells. As a result of this, action of what cell type is compromised?
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CD8+ T cells
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PPD skin test (+) in a pt , who was vaccinated against turberculosis in his native country, reflects response of what cell type?
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CD4+ T lymphocytes (Th1
response --> gamma-IFN) |
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A man with hx of MI is given a morphine injection for a new episode of chest pain; 10 mins later, he has itching and urticaria. Mechanism of this reaction?
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mediators from sensitized mast cells
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A man who now has progressive stupor and laryngeal spasms for 3 days after pt was being attacked by a wild bat in a cave a month ago should have received
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Inactivated rabies virus vaccine
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Defects or deficiency which complements predisposes individuals to infections caused by Neisseria sagents of gonorrhea and meningitis
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C6-C9
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Antimicrobial (immune) response important for intracellular bacterial infections involves cell type
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Th1 CD4 T cells
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Immune response important for viral infections involves cell type
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CD8 cytolytic T cells
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Major antibody in secretions and plays a significant role in first-line defense at the mucosal level is
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IgA
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Main antibody in the initial “primary” immune response and allows good complement activation is
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IgM
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Fc region of this immunoglobulin binds to eosinophils, basophils and mast cells and is significant mediator of allergic (hypersensitivity) reactions
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IgE
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These oxygen-dependent enzymes: NADPH oxidase, superoxide dismutase, and myeloperoxidase are involved in killing of what?
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Gram-positive bacteria
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These oxygen-independent enzymes/proteins: lysosome, lactoferrin, defensins and other cationic proteins are involved in
killing of what? |
Gram-negative bacteria
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The Th1 response, driven primarily by IFN-gamma leads to the activation of
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macrophages
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Inability to control B cell growth in X-linked lympho-proliferative syndrome is associated with
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SH2D1A mutant
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Glomerulonephritis, pulmonary hemorrhage in Goodpasture’s syndrome is caused by what autoantigen?
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basement membrane collagen type IV
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Localized allergies (e.g., drug allergy, asthma, hay fever) and anaphylaxis (food, drug) w/ systemic inflammation throughout circulation are associated with reaction?
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Type I hypersensitivity
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Grave’s Disease, Myasthenia Gravis, Goodpasture’s syndrome are all associated with reaction?
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Type II hypersensitivity
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Poison ivy, erythematous induration in tuberculin skin test, and transplantation/graft rejection are all associated with reaction?
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Type IV hypersensitivity
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