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16 Cards in this Set
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Cyclosporine
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MOA: binds to cyclophilinsand complex inhibits calcineurin. This prevents production of IL-2 and it's receptor. Overall action: blocks differentiation and activation of T-cells.
Use: Organ rejection (acute and chronic are T-cell mediated) and autoimmune disorders Toxicity: High risk of viral infections and lymphoma. Nephrotoxic (prevent with mannitol) |
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Tacrolimus (FK506)
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Mechanism: similar to cyclosporine. binds to FK-binding protein and inhibits secretion of IL-2.
Use: Organ Transplant Toxicity: Significant nephrotoxicity, peripheral neuropathy, hypertension, pleural effusion, hyperglycemia. |
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Azathioprine (AZT)
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MOA: Antimetabolite! precursor to 6MP that interferes with metabolism and synthesis of nucleic acids.
Use: Kidney Transplantation, autoimmune disorders (glomerulonephritis and AIHA) Toxicity: Myelosuppression. Metabolized by xanthine oxidase, so toxicity is increased by allopurinol. |
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Muromonab-CD3 (OKT3)
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MOA: monoclonal Ab binds to CD3. Blocks signal transduction.
Use: Kidney Transplant Toxicity: Cytokine release syndrome, hypersensitivity |
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Siroliumus (Rapamycin)
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MOA: Binds mTOR. Inhibits T-cell proliferation.
Use: Kidney Transplant with cyclosporine and corticosteroids Toxicity: Hyperlipidemia, thrombocytopenia, leukopenia |
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Mycophenolate Mofetil
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MOA: inhibits de novo guanine synthesis and blocks lymphocyte proliferation
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Daclizumab
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MOA: Monoclonal antibody toward IL-2
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Erythropoeitin (epoetin)
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MOA: Recombinant Cytokine
Use: Anemias (prim. renal failure) [must have adequate bone marrow response] |
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Aldesleukin (IL-2)
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MOA: Recombinant Cytokine
Use: Renal Cell Carcinoma, Metastatic Melanoma |
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Filgastrim (G-CSF)
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MOA: Recombinant Cytokine
Use: Bone Marrow Recovery |
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Sargramostim (GM-CSF)
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MOA: Recombinant Cytokine
Use: Bone Marrow Recovery |
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α-interferon (IFN-α)
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MOA: Recombinant Cytokine
Use: Hepatitis B & C, Kaposi's sarcoma, leukemias, malignant melanoma |
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β-interferon (IFN-β)
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MOA: Recombinant Cytokine
Use: Multiple Sclerosis (MS) |
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γ-Interferon (IFN-γ)
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MOA: Recombinant Cytokine
Use: Chronic Granulomatous Disease (CGD) |
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Oprelvekin (IL-1)
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MOA: Recombinant Cytokine
Use: Thrombocytopenia |
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Thrombopoietin
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MOA: Recombinant Cytokine
Use: Thrombocytopenia |
