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8 Cards in this Set
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Azathrioprine
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purine analogue
impedes lymphocyte proliferation and function - suppressing Ig production and T cell proliferation |
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Chlorambucil
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cross-links DNA, prevents cell replication
limited clinical evaluation of use in RA |
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Cyclophosphamide
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cross-links DNA, prevents cell replication
used regularly to treat systemic lupus |
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sulfasalazine
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metabolized to sulfapyridine and 5-aminosalicylic acid
decreases rheumatoid factor production and inhibits lymphocyte proliferative responses inhibits AICAR transformylase, with increase in extracellular adenosine release |
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Hydroxychloroquine
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suppresses lymphocyte proliferative responses
inhibits DNA and RNA synthesis, decreases chemotaxis, and stabilizes lysosomal membranes Can also inhibit TLR-7,9 |
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Leflunomide
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inhibits dihydroorotate dehydrogenase (enzyme in pyrimide synthesis pathway)
inhibits T cell proliferation and immunoglobulin production |
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Mycophenylate mofetil
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active form = mycophenolic acid
inhibits inosine monophosphate dehydrogenase with resultant inhibition of T cell proliferation inhibits expression of adhesion molecules shown to be of benefit for renal disease of lupus, renal transplant maintenance |
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Methotrexate
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inhibits dihydrofolate reductase, which decreases DNA synthesis
inhibits AICAR transformylase, leading to increase in intracellular adenosine (which binds to receptors on lymphocytes, monocytes, and neutrophils) decreases inflammatory responses by decreasing IL-1, IL-8, TNF production by leukocytes |
