Inflammation and Repair

focus of chronic inflammation consisting of an aggregate of macrophages that tend to look like epithelial cells and coalesce into giant cells surrounded by collar of lympohcytes and occasionally plasma cells

Immune granuloma (Tb) central necrosis with amophous debris and acid-fast bacili (caseous necrosis)

Foreign body granuloma (no necrosis)

Usually occurs after traumatic fat necrosis

Persistence (w/ or w/o dystrophic calcification) OR resolve leaving behind a small scar or cavity

inflammation, organization and regeneration, deposition of ECM, remodeling

1st: organization confined to area first cut (no contraction by fibroblasts)
2nd: open wound fills in with granulation tissues; a little more scarring (surface looks the same though)

1)angiogenesis
2) fibroblasts proliferate and make collagen

Note: scar replaces necrotic tissue, unresolved exudates, and blood clots

1 day: neutrophils appear and move toward fibrin colt in the wound

3 days: macrophages replace neutrophils and granulation tissue begins to fill the incision

5 days: granulation tissue fills incision with maximal neoangiogenesis and fibroblast proliferation (not a lot of collagen here--wound is at most vulnerable)

2 weeks: fibroblasts continue to accumulate and make collagen scar

It's a cell that differentiates from a B cell. It consists of extensive, well-developed golgi. RER combined with golgi ideal for secreting antibodies