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25 Cards in this Set
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- Back
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Describe the morphological characteristics of necrosis
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1. Cellular swelling
2. Denatured proteins 3. Breakdown of organelles and plasma membrane 4. Stimulates inflammation 5. Affects contiguous cells |
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Describe the morphological features of apoptosis
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1. Condensation of cytoplasm & nucelus
2. Formation of apoptic bodies 3. Phagocytosis of apoptotic bodies |
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Compare and contrast necrosis and apoptosis
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Apoptosis is a genetically programmed controlled suicide program in cells which do not produce inflammation or scarring, Necrosis is a spontaneous cell death which results in tissue damage, scarring and inflammation
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Define inflammation
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The body's respons to injury and infection to attempt to initiate repair.
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What are the aims of acute inflammation?
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Dilute, destroy, clean up
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What are aims of chronic inflammation?
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Wall off and contain
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What are the general features and compents of acute inflammation?
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1. Early onset (secs to mins)
2. Short duration (mins to days) 3. involves edema, and PMN emigration 4. can lead to resolution (no scarring) or to organisation |
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What are the general features and components of chronic inflammation?
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1. Later onset (days)
2. Longer duration (weeks to years) 3. Involves lymphocytes and macrophages 4. Involves repeated attempts at repair and further injury 5. Will always result in organisation |
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What are the 5 signs of Acut inflammation?
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Heat, redness, swelling, pain, loss of function
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What is the vascular response of acute inflammation?
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vasodilation and increased permeability
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What is the cellular response of acute inflammation?
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leukocyte activation and recuitment
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Define chemotaxis
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Locomotion according to a chemical gradient
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What are the three major components of acute inflammation?
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1. alterations in vacuar caliber that lead to hyperaemia
2. structural changes in the microvasculature 3. emigration of leukocytes to focus of injury |
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define transudate
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extravascular fluid with low protein concentration
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define exudate
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inflammatory extravascular fluid with high protein concentrationq
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which type of extracellular fluid is involved in inflammatory milieus?
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exudate
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What are the two main components of acute inflammation?
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PMNs and macrophages
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Briefly list the five stages of extravasion
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1. Marginisation
2. Rolling 3.Adhesion 4.Diapedesis 5.Migration |
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What are the three outcomes of acute inflammation?
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1. resolution
2. organisation 3. chronic inflammation |
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Define resolution
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repairing constitution of tissue architecture without scar tissue
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Define organisation
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Repair which involves a scar and fibrosis
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What is a mature scar composed of?
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collagen protein
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Prior to full maturation, what is a scar composed of?
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granulation tissue
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What s granulation tissue
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tissue composed of collagen, new angiogenesis macrophages and fibroblasts.
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What is the response to necrosis
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inflammation
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