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18 Cards in this Set
- Front
- Back
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what will be on smear
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blasts with auer roads and/ or myeloperoxidase granules
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what will be in BM biopsy
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> 20% blasts forms
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what types
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1- M0 undifferent
2 - M1withouit maturation 3 M 2 with maturation ( t 18-21) good progn 4. M3 - promyelocytic ( 15.17) chromosome 17 , involvements retinoic aicd Rp on chr 17 ass with DIC, although heparin ius ususally not needed ATRA- A trans retinoic acid is used as maturation agent and then- full chemotherapy good prognosis m4- myelomonocytic-inverted ch 16 peripheral osinophilia, leukemia cutic and CNS disease M5 - monocytic- rearra of ch !! q associated with sopft and skin diseases gingival hyperplasia CNc disease/ hemmorrhage M6- erytroid M7 megacariotic |
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prognosis best factor
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cytogenesis
age adversely affect prognosis secondary AML has a poorer prognosis |
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tx
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1- induction therapy with daunorubcin or idarubicin+ ARA-C cytopsine arabinoside, cytarabine)
if M3 type- add atra, floowed by chemotherapy 2-- ?were cytogenicetics present( mean any chromosomal abnorm) if no--- chemo +ATRA if yes- MB transplanas sson as poosible.. this is best hope for cure 3 leukophoresis if blasts >100.000 or hypo viscosity symptoms |
|
what will be on smear
|
blasts with auer roads and/ or myeloperoxidase granules
|
|
what will be in BM biopsy
|
> 20% blasts forms
|
|
what types
|
1- M0 undifferent
2 - M1withouit maturation 3 M 2 with maturation ( t 18-21) good progn 4. M3 - promyelocytic ( 15.17) chromosome 17 , involvements retinoic aicd Rp on chr 17 ass with DIC, although heparin ius ususally not needed ATRA- A trans retinoic acid is used as maturation agent and then- full chemotherapy good prognosis m4- myelomonocytic-inverted ch 16 peripheral osinophilia, leukemia cutic and CNS disease M5 - monocytic- rearra of ch !! q associated with sopft and skin diseases gingival hyperplasia CNc disease/ hemmorrhage M6- erytroid M7 megacariotic |
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prognosis best factor
|
cytogenesis
age adversely affect prognosis secondary AML has a poorer prognosis |
|
tx
|
1- induction therapy with daunorubcin or idarubicin+ ARA-C cytopsine arabinoside, cytarabine)
if M3 type- add atra, floowed by chemotherapy 2-- ?were cytogenicetics present( mean any chromosomal abnorm) if no--- chemo +ATRA if yes- MB transplanas sson as poosible.. this is best hope for cure 3 leukophoresis if blasts >100.000 or hypo viscosity symptoms |
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the best initial test
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blood smaer - with balsts
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most accurate test
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flow cytometry it will detect he specific CD subtypes , associated wqith each type of leukemia
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most testes facts for acute lekemia are
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M3- gives DIC
add ATRA to tx of M3 auer roads- AML add intrathecal metothrexate to ALL |
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etiology
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myeloproliferatib-ve disorder withclonal proliferation and differe into mature neutrophiles
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clinuical
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assymp with high WBC or fatique
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best initial test
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leukocyte alkaline phosphatase
if increased- leukemo reaction , if not- CML |
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features
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BM- hypercell
phil chrom 22:9... abnormal BCR_ABL... abnormal BCR-ABL throsine kinase |
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disease course
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chronic phase( 2 years untreated) accelerated phase( incre WBC, eosinophilia, basophilia
additiona cytogenic abnorm --- >>> blast crisis ( transform into acute lekemia- 80%AML. 20% ALL |
