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15 Cards in this Set

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Name 2 major forms of Inflammatory Bowel Disease (IBD)
Crohn's disease & Ulcerative coitis
What part of the GIT is affected by Crohn's Disease?
Small & Large intestine & other parts of GIT
What part of the GIT is affected by Ulcerative Colitis?
Rectum & colon are affected (distal intestine)
True or False-- Inflammation in IBD is focal but can affect all layer of the bowel wall.
TRUE
True or False-- IBD can be associated with transluminal complications including abscesses & fistulae.
TRUE
Bowel inflammation & injury are thought to result in...?
...a cascade of events intitiated by putative antigens in genetically susceptible individuals.
What are the responses of IBD?
Diarrhea, ulceration, bleeding, pain, exudation, enteropathy,& malabsorption of nutrients
What are the 7 pharmacological classes of drugs used to treat IBD?
1. Aminosalicylates
2. Glucocorticoids
3. Purine Analogs
4. Methotrexate
5. Cyclosporine
6. Anti TNF- alpha therapy
7. Misc agents
What are the four aminosalicylates used to treat IBD?
Sulfasalazine (Azulfidine)
Olsalazine (Dipentum)
Balsalazide (Colazal)
5- Aminosalicylic acid/ Mesalamine (Asacol, Rowasa)
What is unique characteristic of Olsalazine (Dipentum)? (Hint: structure)
Olsalazine is a dimer of TWO molecules of 5- Aminosalicylic Acid (5-ASA) bound together with an AZO bond.
What is a unique characteristic of Balsalazide (Colazal)?
Balsalazide is 5- Aminosalicylic acid linked to an inert carrier.
Which Aminosalicylate is among the oldest drugs used for treatment of IBD?
Sulfasalazine
Describe Sulfasalazines unique structure.
Conjugate of 5-aminosalicylic acid linked to a sulfapyridine (sulfa drug) by a diazo bond
How is Sulfasalazine broken down in the GIT?
Broken down in the colon by bacterial azo-reductase.
Which component of sulfasalazine is considered to be the therapeutic moiety?
5- Aminosalicylic acid (5-ASA) is considered the main active therapeutic moiety with a minor, if any contribution by sulfapyridine.