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Autoimmune Hemolytic Anemia
Causes |
*IgG Autoantibody binds to RBC cell membrane
*Commonly directed at the RH system *Removal of RBC membrane and spherocyte formation |
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Autoimmune Hemolytic Anemia
Signs & Symptoms |
*Anemia of rapid onset, maybe life threatening
*Fatigue *Angina or CHF *Jaundice *Splenomegaly |
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Autoimmune Hemolytic Anemia
Classic Lab findings |
*HCT less than 10%
*Reticulocytosis *Spherocytes *Severe cases may have nucleated RBC’s *Increased indirect bilirubin *Positive Coombs test (antiglobulin test) *Coincidence of immune thrombocytopenia |
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Autoimmune Hemolytic Anemia
Complications |
Difficult to obtain compatible cross-match with donor’s cells
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Autoimmune Hemolytic Anemia
Typical Tx |
*Initial tx: Prednisone
*Transfusion *Splenectomy if prednisone ineffective |
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