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64 Cards in this Set
- Front
- Back
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a chronic MULTISYSTEM disease related to abnormal insulin production, impaired insulin utilziation or both.
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diabetes mellitus
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the most powerful risk factor for type 2 diabetes is
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obesity
and genetic mutations |
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tissues do not respond to aciton of insulin
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insulin resistance
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where are most insulin receptors located
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skeletal muscle , fat and liver cells.
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when insulin is used improperly, the entry of glucose into the cell is impeded resulting in
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hyperglycemia
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play a role in glucose and fat metabolism and are likely to contribute to type 2 diabetes
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adipokines
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a cluster of abnormlaities that act synergestically to greatly increase the risk for cardiovascular disease and diabetes.
characterized by insulin resistance, elevated insulin levels, high triglycefrides, decreased lipoproteins HDLS anad increased LDLs and hypertension. |
metabolic syndrome
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in type 2 diabetes, sufficient insulin may prevent what from occuring, but with hyperglycemia
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DKA
diabetic ketoacidosis |
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what are the classic symtpoms of the rapid type 1 diabetes
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polytriad
polyphagia, polydipsia, polyuria increased thirst, hunger, pee |
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the intermediate, prediabetic, stage between normal glucose homesstasis and diabetes is called
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impaired glucose tolerance IGT and impaired fasting glucose IFG
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Test that is not used for diabetes diagnostics, but shows amount of glucose attached to hemoglobin molecfules over time, 120 days, indicated overall glucose control for 90-120 days or the life of a redbloodcell
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hemoglobin A1C test
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what is the idea A1C result for diabetics
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6.5-7percent or less
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all individuals with type 1 diabetes require insulin
t/f |
true
ex) exogenous insulin 4-5x perday |
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lantus, which lacks a peak time, is a good type of insulin because it can be taken once daily and has reduced risk for
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hypoglycemia
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overdose of insulin occuring usually during sleep hours, a decline in glucose level.
in the wakening hours , majority of people have the dawn phenomenom |
somygyi effect or dawn phenomenon
treatment dawn phenom = adjust timing of insulin or increase it. treatment of sogymi = less insulin |
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drug of choice for type 2 diabetes because of the decreased chance of prolonged hypoglycemia
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sulfonylureas
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what is the primary action of sulfonlureas
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to increase insulin production from pancrease
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taken just before meals, this oral agent increases insulin from pancrease, mimicking the normal blood glucose response to eating. take 30 min before mealtime. do not take without food
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meglitinides
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ex) metformin/glucophage
reduces glucose production by the liver and enhance insulin sensitivity at tissue level and improve glucose transport to cells |
biguanides
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oral agent that slows down the absorption of carbs in the small intestine. take with meal.
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glucosidase inhibitors
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Test that is not used for diabetes diagnostics, but shows amount of glucose attached to hemoglobin molecfules over time, 120 days, indicated overall glucose control for 90-120 days or the life of a redbloodcell
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hemoglobin A1C test
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what is the idea A1C result for diabetics
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6.5-7percent or less
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all individuals with type 1 diabetes require insulin
t/f |
true
ex) exogenous insulin 4-5x perday |
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lantus, which lacks a peak time, is a good type of insulin because it can be taken once daily and has reduced risk for
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hypoglycemia
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overdose of insulin occuring usually during sleep hours, a decline in glucose level.
in the wakening hours , majority of people have the dawn phenomenom |
somygyi effect or dawn phenomenon
treatment dawn phenom = adjust timing of insulin or increase it. treatment of sogymi = less insulin |
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drug of choice for type 2 diabetes because of the decreased chance of prolonged hypoglycemia
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sulfonylureas
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what is the primary action of sulfonlureas
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to increase insulin production from pancrease
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taken just before meals, this oral agent increases insulin from pancrease, mimicking the normal blood glucose response to eating. take 30 min before mealtime. do not take without food
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meglitinides
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ex) metformin/glucophage
reduces glucose production by the liver and enhance insulin sensitivity at tissue level and improve glucose transport to cells |
biguanides
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oral agent that slows down the absorption of carbs in the small intestine. take with meal.
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glucosidase inhibitors
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when used alone, this will NOT cause hypoglycemia...insulin sensitizers
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thiazolidinediones
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in type 2 diabetics, what is a nutritional goal
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due to obesity, calorie and fat reduction
also promote excercise, weight loss is proven to decrease glucose control |
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a diabetic diet should be
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high in carbs , 45-65 percent of meals...
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diabetics and alcohol is bad...if havae to drink, eat with alcohol, eating carbs is good.
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also effects the liver
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patients taking insulin such as sulfonylureas or meglitinides are at increased ris for hypoglycemia if there is activity or excercise
t/f |
true
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what ethnicities have the biggest prevalance of diabetes
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african americans...native americans, hiospanics
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what are risk factors for diabetes
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ethnicity
baby weighing over 9lbs family history |
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what are visual signs of hypoglycemia
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sweating, tachycardia, termors
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frail elderly patients living alone are at risk of hypoglycemia and should take oral agents that do not cause hypglycemia such as
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shorter acting oral agent
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diabetics should pay most attention to what two areas
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FEET
LOWER EXTREMITIES |
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caused by a profound deficinecy of insulin characvtericed by hyperglycemia, ketosis, acidosis and dehyrdation....most likely in type 1 diabetics...
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diabetic ketoacidosis DKA
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what are acidic byproducts of fat metabolism that can cause problems when excessive in blood
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ketones
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when insulin is insufficent what happens
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glucose cannot be properly used for energy
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a severe depletion of electrolytes, and hypovolemia occurs...renal failure occurs from hypovolemic shock and then ketones and glucose retenetion occurs, untreated pt become dehydrated. eventual death
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DKA
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signs and symptoms of DKA
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ABDOMINAL PAIN
KAUSSMAUL RESPIRATIONS rapid deep breathin w/ dyspnea SWEET FRUITY BREATH BG LEVEL > 300 ph below 7.30 bicarbonate <15 Dry mucous membranes skin turgor poor tachycardia orthostatic hypotension weakness |
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condition where patient is abl;e to prodcue enough insulin to prevent DKA but not enough to prevent hyperglycemia. THIS CAUSES MORE NEUROLOGICAL SYMPTOMS AND IMPAIRED THIRST, INABILITY TO REPLACE FLUIDS
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hyperosmolar hyperglycemic syndrome
HHS |
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HHS manages what , which is the major difference between HHS and DKA
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more fluid replacement
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insulin reactions occur most devastatingly when OA or insulin is
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at its peak or when the pt daility routine is disrupted without adjustments in diet, meds, activity
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hypoglycemia should be treated when
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immediately when the bg is below 70
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how do you treat HYPOGLCEMIA?
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ingesting 15-20 g of a simple fast acting carbs, such as fruit juice or soft drink or milk..
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should hypoglycemic treatment include sweet foods
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NO
should have peanut butter, bread, cheese, crackers |
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one of the leading casues of diabetes related deaths, the rest are due to cardivocascular disease and stroke.
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angiopathy
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diseases of the LARGE and medium size bv that occur with graeter frequency an oearlier onset with diabetics
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macrovascular complications
MACROANGIOPATHY |
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smoking increases the risk for daiebtics deaths
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blood pressure control reduces the risk for cardiovascular disaease heart or stroke
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what results from thickening of the vessel membranes in cappilaries and arterioles in response to chronic hyperglycemia
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microvascular complications
MICROANGIOPATHY |
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the process of microvascular damage to retina as a result of chronic hyperglycemia in diabetics
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diabetic retinopathy
most common is NONPROLIFERATIVE most severe PROLIFERATIVE |
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damage to small bv that supply glomeruli of the kidney
THE LEADING CAUSE OF END STAGE RENAL DISEASE |
diabetic nephropathy
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what is critical to prevention of diabetic nephropathy
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tight GLUCOSE CONTROL
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nerve damage that occurs because of metabolic derangements associated with diabetes mellaitus.
most cfommon is SENSORY |
diabetic neuropathy
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what leads to the loss of sensation in lower extremities
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diabetic NEUROPATHY
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most common form of sensory neuropathy affecting the peripheral nervous system ---- hands or feet....curshing burning pain, worse at night. only treatment is bg control
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sensory neuropathy
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affects all bodyt systems leading to hypoglycemic unawareness...delayed gastric emptying is major complication....erectile dysnfunction., neurogenic bladder develips...
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autonomic neuropathy
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MOST COMMON CAUSE OF HOSPITALIZATION IN PATIENTS WITH DIABETES IS
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foot complications
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a major risk for lower extremity amputation. loss of sensation prevents pat from aware of foot injirtys.
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sensory neuropathy
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