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64 Cards in this Set

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a chronic MULTISYSTEM disease related to abnormal insulin production, impaired insulin utilziation or both.
diabetes mellitus
the most powerful risk factor for type 2 diabetes is
obesity

and genetic mutations
tissues do not respond to aciton of insulin
insulin resistance
where are most insulin receptors located
skeletal muscle , fat and liver cells.
when insulin is used improperly, the entry of glucose into the cell is impeded resulting in
hyperglycemia
play a role in glucose and fat metabolism and are likely to contribute to type 2 diabetes
adipokines
a cluster of abnormlaities that act synergestically to greatly increase the risk for cardiovascular disease and diabetes.

characterized by insulin resistance, elevated insulin levels, high triglycefrides, decreased lipoproteins HDLS anad increased LDLs and hypertension.
metabolic syndrome
in type 2 diabetes, sufficient insulin may prevent what from occuring, but with hyperglycemia
DKA
diabetic ketoacidosis
what are the classic symtpoms of the rapid type 1 diabetes
polytriad

polyphagia, polydipsia, polyuria

increased thirst, hunger, pee
the intermediate, prediabetic, stage between normal glucose homesstasis and diabetes is called
impaired glucose tolerance IGT and impaired fasting glucose IFG
Test that is not used for diabetes diagnostics, but shows amount of glucose attached to hemoglobin molecfules over time, 120 days, indicated overall glucose control for 90-120 days or the life of a redbloodcell
hemoglobin A1C test
what is the idea A1C result for diabetics
6.5-7percent or less
all individuals with type 1 diabetes require insulin

t/f
true

ex) exogenous insulin 4-5x perday
lantus, which lacks a peak time, is a good type of insulin because it can be taken once daily and has reduced risk for
hypoglycemia
overdose of insulin occuring usually during sleep hours, a decline in glucose level.

in the wakening hours , majority of people have the dawn phenomenom
somygyi effect or dawn phenomenon

treatment dawn phenom = adjust timing of insulin or increase it.

treatment of sogymi = less insulin
drug of choice for type 2 diabetes because of the decreased chance of prolonged hypoglycemia
sulfonylureas
what is the primary action of sulfonlureas
to increase insulin production from pancrease
taken just before meals, this oral agent increases insulin from pancrease, mimicking the normal blood glucose response to eating. take 30 min before mealtime. do not take without food
meglitinides
ex) metformin/glucophage

reduces glucose production by the liver and enhance insulin sensitivity at tissue level and improve glucose transport to cells
biguanides
oral agent that slows down the absorption of carbs in the small intestine. take with meal.
glucosidase inhibitors
Test that is not used for diabetes diagnostics, but shows amount of glucose attached to hemoglobin molecfules over time, 120 days, indicated overall glucose control for 90-120 days or the life of a redbloodcell
hemoglobin A1C test
what is the idea A1C result for diabetics
6.5-7percent or less
all individuals with type 1 diabetes require insulin

t/f
true

ex) exogenous insulin 4-5x perday
lantus, which lacks a peak time, is a good type of insulin because it can be taken once daily and has reduced risk for
hypoglycemia
overdose of insulin occuring usually during sleep hours, a decline in glucose level.

in the wakening hours , majority of people have the dawn phenomenom
somygyi effect or dawn phenomenon

treatment dawn phenom = adjust timing of insulin or increase it.

treatment of sogymi = less insulin
drug of choice for type 2 diabetes because of the decreased chance of prolonged hypoglycemia
sulfonylureas
what is the primary action of sulfonlureas
to increase insulin production from pancrease
taken just before meals, this oral agent increases insulin from pancrease, mimicking the normal blood glucose response to eating. take 30 min before mealtime. do not take without food
meglitinides
ex) metformin/glucophage

reduces glucose production by the liver and enhance insulin sensitivity at tissue level and improve glucose transport to cells
biguanides
oral agent that slows down the absorption of carbs in the small intestine. take with meal.
glucosidase inhibitors
when used alone, this will NOT cause hypoglycemia...insulin sensitizers
thiazolidinediones
in type 2 diabetics, what is a nutritional goal
due to obesity, calorie and fat reduction

also promote excercise, weight loss is proven to decrease glucose control
a diabetic diet should be
high in carbs , 45-65 percent of meals...
diabetics and alcohol is bad...if havae to drink, eat with alcohol, eating carbs is good.
also effects the liver
patients taking insulin such as sulfonylureas or meglitinides are at increased ris for hypoglycemia if there is activity or excercise

t/f
true
what ethnicities have the biggest prevalance of diabetes
african americans...native americans, hiospanics
what are risk factors for diabetes
ethnicity
baby weighing over 9lbs
family history
what are visual signs of hypoglycemia
sweating, tachycardia, termors
frail elderly patients living alone are at risk of hypoglycemia and should take oral agents that do not cause hypglycemia such as
shorter acting oral agent
diabetics should pay most attention to what two areas
FEET
LOWER EXTREMITIES
caused by a profound deficinecy of insulin characvtericed by hyperglycemia, ketosis, acidosis and dehyrdation....most likely in type 1 diabetics...
diabetic ketoacidosis DKA
what are acidic byproducts of fat metabolism that can cause problems when excessive in blood
ketones
when insulin is insufficent what happens
glucose cannot be properly used for energy
a severe depletion of electrolytes, and hypovolemia occurs...renal failure occurs from hypovolemic shock and then ketones and glucose retenetion occurs, untreated pt become dehydrated. eventual death
DKA
signs and symptoms of DKA
ABDOMINAL PAIN
KAUSSMAUL RESPIRATIONS
rapid deep breathin w/ dyspnea
SWEET FRUITY BREATH

BG LEVEL > 300
ph below 7.30
bicarbonate <15

Dry mucous membranes
skin turgor poor
tachycardia
orthostatic hypotension
weakness
condition where patient is abl;e to prodcue enough insulin to prevent DKA but not enough to prevent hyperglycemia. THIS CAUSES MORE NEUROLOGICAL SYMPTOMS AND IMPAIRED THIRST, INABILITY TO REPLACE FLUIDS
hyperosmolar hyperglycemic syndrome
HHS
HHS manages what , which is the major difference between HHS and DKA
more fluid replacement
insulin reactions occur most devastatingly when OA or insulin is
at its peak or when the pt daility routine is disrupted without adjustments in diet, meds, activity
hypoglycemia should be treated when
immediately when the bg is below 70
how do you treat HYPOGLCEMIA?
ingesting 15-20 g of a simple fast acting carbs, such as fruit juice or soft drink or milk..
should hypoglycemic treatment include sweet foods
NO

should have peanut butter, bread, cheese, crackers
one of the leading casues of diabetes related deaths, the rest are due to cardivocascular disease and stroke.
angiopathy
diseases of the LARGE and medium size bv that occur with graeter frequency an oearlier onset with diabetics
macrovascular complications

MACROANGIOPATHY
smoking increases the risk for daiebtics deaths
blood pressure control reduces the risk for cardiovascular disaease heart or stroke
what results from thickening of the vessel membranes in cappilaries and arterioles in response to chronic hyperglycemia
microvascular complications

MICROANGIOPATHY
the process of microvascular damage to retina as a result of chronic hyperglycemia in diabetics
diabetic retinopathy

most common is NONPROLIFERATIVE

most severe
PROLIFERATIVE
damage to small bv that supply glomeruli of the kidney

THE LEADING CAUSE OF END STAGE RENAL DISEASE
diabetic nephropathy
what is critical to prevention of diabetic nephropathy
tight GLUCOSE CONTROL
nerve damage that occurs because of metabolic derangements associated with diabetes mellaitus.

most cfommon is SENSORY
diabetic neuropathy
what leads to the loss of sensation in lower extremities
diabetic NEUROPATHY
most common form of sensory neuropathy affecting the peripheral nervous system ---- hands or feet....curshing burning pain, worse at night. only treatment is bg control
sensory neuropathy
affects all bodyt systems leading to hypoglycemic unawareness...delayed gastric emptying is major complication....erectile dysnfunction., neurogenic bladder develips...
autonomic neuropathy
MOST COMMON CAUSE OF HOSPITALIZATION IN PATIENTS WITH DIABETES IS
foot complications
a major risk for lower extremity amputation. loss of sensation prevents pat from aware of foot injirtys.
sensory neuropathy